Six-times champion and top seed Roger Federer lost 6-4 3-6 6-1 6-4 to Czech Tomas Berdych in the quarter-finals of Wimbledon on Wednesday.
The defeat means Federer will be absent from the men's final for the first time since 2002 when he lost in the first round.
World number two Federer, who had endured a shaky start to the grasscourt tournament, was outplayed by the tall Czech in front of a capacity Centre Court crowd.
He saved one match point with a volley at the net but Berdych finally completed his third career victory over the Swiss with a forehand winner.
Berdych will face Novak Djokovic in the semi-finals after the third seed comfortably saw off Andy Roddick's conqueror Lu Yen-hsun of Taiwan.