Mario Gomez scored a last-ditch winner to give Bayern Munich a 1-0 win at titleholders Inter Milan in a repeat of last year's Champions League final on Wednesday.
Inter keeper Julio Cesar failed to hold a long-range shot from Arjen Robben and Gomez pounced on the rebound to score in the final minute of normal time.
Bayern, 2-0 losers in Madrid last season to the team then coached by Jose Mourinho, looked more dangerous throughout the last 16 first leg tie, although the hosts also created openings.
Inter had an early chance when defender Andrea Ranocchia side-footed wide from a free kick but Bayern then looked more threatening.
Luiz Gustavo was twice close while Franck Ribery, always dangerous with the ball at his feet, headed against the crossbar from Robben's curling cross.
Samuel Eto'o was Inter's most threatening player, having a penalty appeal turned down, creating a good chance for Esteban Cambiasso and then producing a brilliant reflex save from Thomas Kraft before halftime.
Fullback Maicon had Inter's best first half chance in stoppage time when was given a clear shot on goal but fired wide.
Robben continually tormented Inter and hit the post early in the second half, then struck another effort over the crossbar after cutting inside with one of his trademark runs.
In between, Inter missed a sitter when Eto'o had another shot saved by Kraft and Cambiasso, unmarked, fired over from the rebound.
Inter finished with a flourish as Thiago Motta was foiled by Kraft and an Eto'o shot went agonisingly wide.
Robben told Sky television he thought Bayern had been the better team throughout and deserved their win, athough it was no consolation for last year's loss.
"We expect Italian teams to play very defensive and very compact," he said. "Tonight was very important, they are an Italian team and very dangerous. The tie isn't over yet."