Arsenal produced perhaps one of their finest performances under Arsene Wenger to dethrone AC Milan, beating the Champions League holders 2-0 on the night and on aggregate in their last 16 second leg clash.
Arsenal's great Premiership rivals Manchester United, who had started a run of four matches without a win for the Gunners prior to yesterday - also eased through with a 1-0 victory at home to six-time French champions Lyon, thanks to Portuguese wizard Cristiano Ronaldo's 30th goal in 30 matches this term.
Turkish side Fenerbahce also produced an outstanding away performance as they made the last eight for the first time, beating Spanish outfit Sevilla in a penalty shootout after the match ended 5-5 on aggregate (3-2 to Sevilla on the night).
That ended the hosts dreams of a third successive European crown, having won the last two UEFA Cups.
Spanish pride was saved by Barcelona, who downed Arsenal in the 2006 Champions League final, as they beat Celtic 1-0 in Barcelona, thanks to an early goal by Xavi for a 4-2 aggregate win.
It was Arsenal, though, who really pulled out all the stops to become the first English side to beat AC Milan at the San Siro and complete a full house as it were having already beaten Inter Milan there before.
Late goals by Cesc Fabregas and Emmanuel Adebayor, his first ever Champions League goal, saw the Gunners into the last eight and understandably left manager Arsene Wenger with a smile like a Cheshire Cat.
"We produced the match we wanted to," said the Frenchman.