Javier Hernandez saved Manchester United's blushes as the Premier League leaders came from behind to defeat Southampton 2-1 and advance to the last 16 of the FA Cup on Saturday.
Hernandez slid home a 75th-minute winner after a Michael Owen header for an under-strength United had cancelled out a stunning strike from Richard Chaplow which had given Southampton the lead just before half-time.
United manager Sir Alex Ferguson fielded a virtual second string side at St Mary's, with Wayne Rooney, Ryan Giggs, Dimitar Berbatov and Nani all left on the substitutes bench.
In earlier matches Saturday, Chelsea maintained their bid for a third consecutive FA Cup after snatching a 1-1 draw with Everton while non-league Crawley advanced to with a 1-0 win over Torquay.
A goal from Salomon Kalou on 75 minutes earned Chelsea a draw at Goodison Park after the Toffees had taken a deserved lead through a 62nd-minute headed effort from Louis Saha.
"It was a difficult match because Everton put a lot of strong pressure on us all the time," Chelsea manager Carlo Ancelotti told ESPN. "We showed good spirit. The second half we didn't play well but the spirit was good."
Crawley meanwhile became only the sixth non-league side to reach the fifth round after Matthew Tubbs scored on 39 minutes to down the Gulls in a stormy encounter at Plainmoor.
Crawley, who had knocked out Swindon and Derby in earlier rounds, missed two second-half penalties as both sides finished with 10 men.
"We expected to come here and win. We said it and we have done it," said jubilant Crawley boss Steve Evans.
"We are just proud to get where we are and now we are in the fifth round we would like the draw to be kind to us. If it is, then fantastic, but whoever we get in the fifth round, we will go and try and win like we did today."
In other matches Saturday, lowly League One side Leyton Orient were the first team to reach the last 16 with a 2-1 upset away at Championship outfit Swansea, before Aston Villa downed Blackburn 3-1 in an all-Premier League tie.
Villa's goals included the first for the club from French veteran Robert Pires, who earned praise from manager Gerard Houllier afterwards.
"He has still got the touch and the eye for the pass and he brings some fluency to the game with his technique," Houllier said.
"I was pleased by the reaction of the bench when he scored. That is something very telling. The whole bench went up and were very happy and proud for him. He is a popular fellow."
Birmingham staged a dramatic fightback against midlands rivals Coventry to advance, recovering from 2-0 down to win 3-2 at St Andrews thanks to goals from David Bentley, Stuart Parnaby and Kevin Phillips.
Burnley defeated Burton Albion 3-1 while Championship side Watford were stunned 1-0 at Vicarage Road by Brighton from League One.
League Two Stevenage, conquerors of Newcastle in the previous round, saw their hopes of an extended cup run extinguished by Reading, who grabbed a 2-1 win courtesy of an 87th-minute strike from Shane Long.
In the day's other meeting between two Premier League clubs, Bolton drew 0-0 with Wigan at the Reebok Stadium.
Three-time FA Cup winners Sheffield Wednesday advanced to the fifth round after recovering from a goal down to beat Hereford 4-1.
On Sunday Manchester City face an away tie against Notts County while Fulham entertain Tottenham at Craven Cottage.
Arsenal play Huddersfield at the Emirates and West Ham take on Nottingham Forest at Upton Park, while Wolves face Stoke.