Everton's Andy Johnson is set to miss England's Euro 2008 qualifer against Estonia next month after his club confirmed he must undergo surgery at the end of the season.
The 26-year-old striker suffered an injury to his right ankle but it is his left ankle that requires an operation.
He is destined to miss out on England's friendly with Brazil on June 1 and the trip to Estonia five days later.
Everton head physiotherapist Mick Rathbone told the club's official website, on Wednesday, "After injuring his right ankle, we were hopeful that the subsequent period of rest would help his left ankle."
"However, that has not been the case and the player will have an operation as soon after the final match of the season as possible."
"Andy has had the problem for a number of months now and it is getting no better."
The news comes as a blow to England boss Steve McClaren who will now be hoping Michael Owen will have made a full recovery from the injury he suffered in last year's World Cup.