Bayern Munich secured a place in the Champions League last 16 with an impressive 4-1 win at Juventus as former European champions Real Madrid and AC Milan also advanced to the knockout stage on Tuesday.
Juventus were eliminated after Bayern came from behind to end the home side's 16-match unbeaten home run in Europe's premier club competition.
Juve, who only needed a draw to progress from Group A, looked set to go through after David Trezeguet volleyed the Italians into an early lead but a second-half collapse resulted in their most emphatic home defeat in Europe.
“No one expected us to win like this so it makes the victory even better,” Bayern's Dutch coach Louis Van Gaal said.
Croatia striker Ivica Olic was instrumental in Bayern's success. He won a penalty converted by goalkeeper Hans Joerg-Butt and then gave the German side the lead before Mario Gomez and Anatoly Tymoshchuk completed the rout.
Bayern finished as runners-up in the group, won by French champions Girondins Bordeaux who completed their impressive group stage campaign with a 1-0 success at Maccabi Haifa.
A Cristiano Ronaldo brace and a third by Raul Albiol handed Real Madrid a 3-1 Group C win at Olympique Marseille.
Milan, who drew 1-1 at Zurich, looked in danger after a Milan Gajic free kick gave the home side a 29th-minute lead, but Ronaldinho's penalty combined with Real's win saw the 2007 winners through.
Michael Owen scored his first hattrick in a Manchester United shirt, giving the injury-hit English champions a 3-1 win at German title holders Wolfsburg in Group B which stretched their unbeaten away run to 15 games in the Champions League.
The striker, who joined United from Newcastle on a free transfer during the close-season, headed Alex Ferguson's team ahead on the stroke of halftime after a perfect cross by Portugal winger Nani.
Edin Dzeko revived Wolfsburg's hopes with a close-range header before Owen restored United's lead and then sealed the win with a classy goal in injury time.
United won their group and were joined in the last 16 by Russia's CSKA Moscow, who went through thanks to a 2-1 win at Turkey's Besiktas.
Serbia winger Milos Krasic fired CSKA into the lead with an angled shot and midfielder Yevgeny Aldonin netted their injury time winner.
CSKA, who completed their recovery from a poor start with two wins and a draw in their final three games, could be joined in the last 16 by Russian champions Rubin Kazan.
Chelsea, who had earlier clinched Group D, were held to a surprise 2-2 home draw by Apoel Nicosia while second-placed Porto eased to a 3-0 win at Atletico Madrid.
UEFA suspends Moscow duo for doping
German champions Wolfsburg said they hope to be included in the draw for the last 16 of the Champions League after UEFA suspended two CSKA Moscow players for flouting anti-doping rules.
Wolfsburg are third in Group B behind United and second-placed CSKA, and out of the competition.
However the German club believe they should be going through to the next round because two of CSKA's players — Sergei Ignashevich and Alexei Berezutsky — had tested positive for the stimulant pseudoephedrine.
“If there were a case of doping, it would not be fair that CSKA Moscow takes part in the knock-out phase,” Wolfsburg's managing director Jurgen Marbach said.
“We have contacted UEFA and we are waiting to see what will be decided. In other sports, doping offences are always sanctioned heavily and it must be the same in football.”
The controversy emerged Tuesday when CSKA announced that UEFA had suspended the two defenders for that night's match against Besiktas.
The club blamed a “technical mistake” on the part of the team doctor who forgot to declare that the pair had been taking a common cold remedy, Sudafed, which contains pseudoephedrine.
Although not currently banned pseudoephedrine is on WADA's 'monitored' products list. As of January 1, 2010, it will be back on WADA's banned list.
Wolfsburg now hope their appeal will see them included when the last 16 draw is made on December 18.