Manchester United striker Wayne Rooney scored two penalties but defender Nemanja Vidic was controversially sent off as they kick-started their Champions League Group C campaign with a 2-0 win over Romanians Otelul Galati in Bucharest on Tuesday.
Manchester City notched up their first ever Champions League win with Sergio Aguero scoring in the third minute of stoppage time to give them a 2-1 victory over Spaniards Villarreal, who heartbreakingly lost for the third straight match in Group A.
City remained third in the group however after the top two, Bayern Munich and Napoli, drew 1-1 in Italy.
Rooney slammed in his first penalty for United after 64 minutes and his second two minutes into added time to give United their first win in Group C.
Vidic was unfortunate to be red-carded for what looked like a high, but not dangerous, challenge on Gabriel Giurgiu.
The Romanian champions had Milan Perendija sent off for a second yellow card for a foul two minutes from time.
Napoli hold Bayern
Naples: Morgan De Sanctis saved a second-half penalty from Mario Gomez as Napoli earned a 1-1 draw against a dominant Bayern Munich in a lively Champions League Group A encounter on Tuesday.
Bayern struck first with only two minutes on the clock when Toni Kroos was allowed acres of space inside the Napoli box before placing his shot into the corner.
Napoli equalised on 39 minutes when Christian Maggio's right-wing cross was deflected into the net by Holger Badstuber's lunging dive.
Inter see off Lille
Milan: Struggling Inter Milan gave their season a much-needed shot in the arm here on Tuesday as Giampaolo Pazzini's first-half strike proved enough to beat Lille 1-0 in Champions League group B. Pazzini volleyed home midway through the first period before Inter dug deep to claim their second win in the group and seize top spot from CSKA Moscow, who beat Trabzonspor 3-0 earlier in the day.
Real crush Lyon
Madrid: Real Madrid swept aside Olympique Lyon 4-0 on Tuesday, a third consecutive victory leaving them clear at the top of Champions League Group D.
Goals by Karim Benzema, Sami Khedira, Mesut Ozil and Sergio Ramos made sure Jose Mourinho's side had an easy day at the office.
France striker Benzema tapped in at the far post in the 19th minute to leave his former club on the rack as Madrid were utterly dominant at the Bernabeu.
Midfielder Khedira scored from Benzema's cross in the 47th minute and fellow German Ozil bagged the third soon after, Lyon keeper Hugo Lloris helping the ball into his own net. Ramos also smashed in a volley near the end.
Lyon, who have four points from three games, showed little ambition and sat deep in their own half for most of the time.
Cristiano Ronaldo glanced a corner towards the back post and Benzema slid in to score the opener as Real threatened to completely overwhelm the visitors.
Lyon's Bafetimbi Gomis had a goal ruled out for offside in the 28th minute but it was a rare attacking foray.