Fourth seeds Leander Paes and Martin Damm went down to top seeds Bob and Mike Bryan in the semifinals of the $2,200,000 Cincinnati Masters in Toronto, Canada.
The Indo-Czech pair squandered a one-set lead to go down 3-6 6-0 10-7 to the Americans, who advanced to their 12th final this year.
The top seeds will take on the sixth seeded Israeli duo of Jonathan Erlich and Andy Ram, who defeated Czechs Lukas Dlouhy and Pavel Vizner 7-6 (4) 7-5, in the finals on Saturday.
Paes and Damm were off to a brilliant start as they broke Mike Bryan's first service game en route to capturing the first set.
However, the Indo-Czech pair completely lost the plot in the second set and was blanked out by the Bryans.
The top seeds then raced to an 8-2 lead in the tie-break but Paes and Damm recovered to cut the lead to 8/7.
The comeback, however, proved to be too late as Bob Bryan fired a couple of un-returnable serves to clinch the match after 58 minutes.
The Bryan brothers have already won a personal-best eight titles this year.