Cristiano Ronaldo came off the bench to seal a 3-0 win for Real Madrid away to Espanyol in La Liga on Saturday, while Zlatan Ibrahimovic provided the inspiration for Barcelona in a 2-0 success at Getafe.
Esteban Granero struck to give Real the lead just before the break, Guti made it 2-0 and Ronaldo wrapped up the victory in added time.
It was an emotional evening for the Espanyol players and fans as it was their first home league match since captain Dani Jarque collapsed and died last month and their first competitive game in their new Cornella-El Prat stadium.
Barcelona had earlier got their second win from two when Ibrahimovic scored one and created the clinching second for Lionel Messi.
Barcelona are top with six points, ahead of Real on goal difference.
Earlier, Barca coach Pep Guardiola left Messi, Thierry Henry, Daniel Alves and fit-again Andres Iniesta on the bench and the European champions came under pressure.
Guardiola brought on Messi and Iniesta just before the hour and they took the lead almost immediately when Ibrahimovic stuck out a leg to deflect the ball in off a post from Eric Abidal's deflected cross.
Debutant Caceres seals Juventus win
Martin Caceres scored on his Serie A debut to help Juventus win 2-0 at Lazio on Saturday and maintain their perfect start to the season.
The Uruguay right back, on loan from Barcelona, smashed home a loose ball on the edge of the box midway through the second half.
David Trezeguet, starting up front, secured a victory late on when he tucked in from close range.
Juve's third win from three came at a cost with new playmaker Diego, who scored twice in the 3-1 win over Roma on their previous visit, going off before the break with a leg injury.
AC Milan were held to a 0-0 draw at promoted Livorno. Stuttering Milan must now prepare for their return to the Champions League in the clash at Marseille on Tuesday, when Juve host Bordeaux.
New strikers Samuel Eto'o and Diego Milito scored in second half and Inter Milan beat Parma 2-0 on Sunday to stay within two points of A title rival Juventus. Roma on 2-1 over 10-man Siena in Claudio Ranieri's first match as the manager of the club.