Sania Mirza's US Open campaign came to an end on Saturday with a straight-set loss to Russian sixth seed Anna Chakvetadze in the third round.
Sania, the first Indian woman to be seeded at a Grand Slam, went down 6-2, 6-3 to Chakvetadze in 53 minutes.
Twenty-sixth seeded Sania has now lost all her four encounters against the Russian.
Earlier, Sania and Mahesh Bhupathi shocked seventh seeds Elena Likhovtseva and Daniel Nestor in straight sets to advance to the second round of the US Open here.
The Indian pair beat the Canadian-Russian duo 6-0 6-2.
Bhupathi and Sania will now brace up for a tougher challenge in the second round as they will take on the fifth seeded Czech pair of Kveta Peshcke and Martin Damm.