Being the first Indian woman to be seeded at the US Open earned Sania Mirza a relatively easy draw and the Hyderabadi would kick off her campaign in the Grand Slam event with a first-round outing against Estonian Kaia Kanepi.
World number 28 Sania, seeded 26th in the season's last Grand Slam, would be facing the 44th-ranked Kanepi for the first time in her career.
Both Sania and Kanepi had made third-round exits at Flushing Meadows last year.
If Sania overcomes the challenge from her unseeded opponent, she will be up against the winner of the other first-round match between 24th seeded Francesca Schiavone of Italy and Nathalie Dechy of France.
The only area where the 22-year-old Kanepi stands above Sania is her height. The Estonian, who is 5'11, is however, way behind in other statistics.
While Sania has to her credit a WTA title in 2005 Hyderabad Open, Kanepi is yet to make her mark at the WTA circuit despite having a few ITF titles to her name.
Sania will go into the championship high on confidence after her impressive performance on the US hardcourts this season.