Portsmouth strikers Jermain Defoe and Peter Crouch inflicted a 2-0 loss on Tottenham to deepen the turmoil at their former side, while newly enriched Manchester City was upset 2-1 at Wigan with both beaten sides unhappy with penalty decisions.
Defoe scored from the penalty spot in the 34th minute on Sunday for his 13th goal in 18 games since being sold by Tottenham.
The victory was sealed in the 66th by Crouch, who was let go by Spurs in 2000 without making a competitive appearance.
But Tottenham, which is off to its worst league start in 53 years, departed Fratton Park with a sense of injustice after referee Mike Dean refused to award a penalty when Lassana Diarra blocked Aaron Lennon's cross with his hand in the 54th - despite Jermaine Jenas being penalized for the same offense in the first half.
City felt similarly aggrieved at Wigan, with manager Mark Hughes branding referee Steve Bennett's decisions "erratic" and "mystifying."
City, which trounced Portsmouth 6-0 last weekend, was fuming at a contentious penalty decision that let Amr Zaki score the winner for Wigan. There appeared to have been minimal contact when Bennett ruled that Javier Garrido brought down Wilson Palacios in the 34th.
City captain Richard Dunne then thought he should have been awarded a spot kick when clipped by Emile Heskey before the break.
Antonio Valencia put Wigan ahead in the 16th, but Vincent Kompany leveled from close range five minutes later.
City, which was embarrassingly eliminated from the League Cup on Wednesday by third-tier Brighton, has now lost both games since the completion of a takeover by an Abu Dhabi investment group.