Chelsea's perfect start to the season ended with a 3-1 loss at Wigan on Saturday, allowing defending champion Manchester United to go top in the Premier League by winning 2-0 at Stoke.
Chelsea goalkeeper Petr Cech was sent off early in the second half for tripping Hugo Rodallega, who proceeded to make it 2-1 from the penalty spot and condemn Carlo Ancelotti to his first loss as Chelsea manager.
Strikes from Dimitar Berbatov and John O'Shea ensured United moved above Chelsea on goal difference.
Liverpool and Tottenham are both three points adrift after emphatic victories.
Fernando Torres scored a hat trick in Liverpool's 6-1 win over Hull, and Robbie Keane hit four goals as Tottenham thrashed Burnley 5-0.
Portsmouth's worst start continued, losing 1-0 against Everton for its seventh straight league defeat to remain pointless and rooted to the bottom. Everton's Louis Saha scored in the 42nd minute at Fratton Park for his seventh goal of the season. Also on Saturday, Bolton won 2-1 at Birmingham and Blackburn defeated Aston Villa by the same score.
Arsenal was at Fulham in the late match.