Conference known for an inspiring mix of influential big thinkers and "ideas worth spreading.
He playfully demonstrated his point on stage by ignoring a theater audience to stare down at his smartphone, saying he was intent on a message from a Nigerian prince need of $10 million dollars.
"I like to pay attention because that is how we originally funded the company," the Google co-founder quipped about a well-known scam.
"Seriously, in addition to potentially socially isolating yourself when you are out and about using your phone, I feel it is kind of emasculating," he continued.
Brin described Glass as the first form factor to deliver on a vision he had from Google's inception that one day search queries would be outmoded and information from the Internet would come to people when they need it.
Glass frees the eyes as well as the hands when it comes to connecting to the Internet on the go, according to Brin.
"That is why we put the display up high, out of the line of sight," Brin said, wearing the Glass eyewear he is rarely seen without.
"If I wore a ball cap, the display would be on the brim and not where you are looking," he continued. "And sound goes through bones in the cranium, which is a little freaky at first, but you get used to it."
Glass wearers can speak commands to the eyewear, and built-in camera technology allows pictures or video to be captured from first-person perspectives while people take part in what is happening.
"Lastly, I realized I also have a nervous tic," Brin said. "The cell phone is a nervous habit. If I smoked, I'd probably smoke instead."
He observed that smartphones sometimes become props used by people as distractions or to appear busy, saying that Glass strips away excuses not to be sociable or to not be honest about simply wanting to take a break.
"It really opened by eyes to how much of my life I spent secluded away in email, social posts or what-not," Brin said. "There is nothing bad about that, but with this thing I don't have to be checking them all the time."
Brin said Glass eyewear will be available later this year at prices lower than the $1,500 charged to software developers and early adopters during a restricted test phase.
Wednesday was the last day for "explorers" with creative vision and $1,500 to spare to vie to be part of a select group of people who get to experiment with Glass.
A video intended to capture what it feels like to use Glass was online at google.com/glass/start/.
Google has been speaking with eyeglass frame companies about ideas for a consumer version of the glasses, which he expected would cost "significantly" less than the Explorer prototypes.
US adults interested in the program had to say what they would do if they had Glass eyewear and then post the messages at Twitter or Google+ social networks with hashtag #ifihadglass.
People chosen for the Explorer program will need to pick up in person at sessions to be held in New York, Los Angeles, or San Francisco.