Five-time champion Venus Williams battled past Croatian teenager Donna Vekic 7-6 (7/3), 6-4 to make a winning start to her Wimbledon 2016 campaign on Monday.
Williams, 36, is the oldest woman in the main draw of this year’s tournament and first won Wimbledon in 2000 when Vekic was just four.
The world number eight, playing in a record-equalling 71st Grand Slam, will play Greek qualifier Maria Sakkari for a place in the third round.
Former world number one Ana Ivanovic was knocked out, losing 6-2, 7-5 to Russian qualifier, Ekaterina Alexandrova, the world 223.
Ivanovic, the 2008 Roland Garros champion and a semi-finalist at the All England Club in 2007, suffered just her second opening round loss at Wimbledon in 12 visits.
Alexandrova, 21, is making her Grand Slam debut and had won just one match on the main tour in her entire career before Monday’s shock win over the 23rd seed.
Ivanovic said she was suffering a right wrist injury and won’t play again until the Rio Olympics.
“I need to rest it and get and MRI scan. It’s harder on grass with the wrist like that because the balls skids through,” she said.
Croatian ninth seed and former US Open winner Marin Cilic saw off Brian Baker of the United States 6-3, 7-5, 6-3 and Spanish 13th seed David Ferrer was a 6-2, 6-1, 6-1 winner over Israel’s Dudi Sela.
Women’s ninth seed Madison Keys was a 6-3, 6-1 victor over Germany’s Laura Siegemund.
The Centre Court programme later Monday also sees women’s second seed and French Open champion Garbine Muguruza taking on Camila Giorgi, the world number 68 from Italy.
Muguruza was runner-up to Serena Williams last year. Giorgi reached the fourth round in 2012.
On Court One, Japanese fifth seed Kei Nishikori, who has yet to get beyond the fourth round, takes on big-serving Australian Sam Groth.
Australian Open champion Angelique Kerber faces Britain’s Laura Robson in the same arena.
Canadian sixth seed Milos Raonic, with John McEnroe in his corner, meets Spain’s Pablo Carreno Busta as he looks to improve on his 2014 semi-final showing.