Sevilla dominated the rest of the game after that as Wolves increasingly tired in its 59th game of a long season. A goal looked inevitable and Lucas Ocampos delivered with a header to win the game in the 88th minute.
Arsenal said players will be isolated for 14 days after coming into contact with the owner of Greek club Olympiakos, who has tested positive for COVID-19.
Ajax, Celtic, Benfica and Porto went out but Manchester United hardly broke sweat after Simon Deli of Brugge conceded a penalty and earned a red card in the 23rd minute at Old Trafford and won 5-0.
Arsenal are expecting a hostile reception for the first leg of their round of 32 tie in Piraeus, where Olympiakos have lost just once -- against Bayern Munich -- this season.
Kovac, 48, was dismissed by Bayern last Sunday in the wake of a 5-1 thrashing at Eintracht Frankfurt. Interim coach Hansi Flick oversaw a 2-0 home win over Olympiakos in midweek, with Bayern qualifying for the last 16 of the Champions League.