Hollywood beauty Theron will host the show for the second time on May 10 episode. She will be joined by The Black Keys, who will make their third appearance as musical guest, reported Ace Showbiz.
Former SNL cast member Samberg, who currently stars on FOX's hit comedy Brooklyn Nine-Nine, will host the May 17 episode. St Vincent will make her musical guest debut in the same outing.
Andrew Garfield has also been tapped for the TV series. He will make his SNL hosting debut with Coldplay returning for their fifth musical guest appearance.