the Once train station in Buenos Aires, where 51 people died and 700 were injured in February 2012, when a train slammed into a retaining wall.
Railway officials said Saturday's accident occurred at 7:25am (1025 GMT) and that there had been no earlier reports of problems during the train's ride.
Officials said they could could not immediately determine the cause of the accident and that the injured were rushed to about a dozen nearby hospitals via some 30 ambulances and two helicopters.
Television footage showed various railway cars that had left the track and were on the platform after the train apparently failed to stop at the end of the line.
Passengers who emerged from the wrecked train cars described a chaotic scene of people being thrown to the floor when the train made impact. Many passengers were trapped onboard until they could be rescued by firefighters.
One witness said shaken passengers became enraged and accosted the motorman.
"People were shouting 'murderer' at him," said a man by the name of Julio who said he was a passenger in the third car.
The train seemed as if it "was having trouble braking for two stations" prior to its arrival at the Once station, Julio said, adding his fellow passengers "were getting nervous, as they remembered" last year's disaster at the same train station.
Buenos Aires has been plagued by rail accidents in recent years.
In addition to last February's deadly collision, there have been numerous incidents, including a serious collision in June of this year, when a speeding commuter train slammed into another train that had stopped between stations, killing three people and injuring more than 300.
Authorities said it was fortunate that, unlike the earlier major mishaps, today's crash did not happen on a busy weekday, and that the train was only partially full.
Argentina has tried to ramp up oversight of its problem-plagued train system since last year's deadly train collision.
And, after June's deadly collision, officials put surveillance cameras in conductors' cabs.
The increased surveillance has already revealed some acts of negligence by railway personnel, officials said in July.