Three people were killed and 15 others, including women and children, injured as several missiles on Monday hit a madrassa in Pakistan's restive North Waziristan tribal region, which houses Taliban leader Jalaluddin Haqqani's residence.
A drone operated by US-led forces in Afghanistan fired six to seven guided missiles at the seminary in Tanda Darpakhel, two kilometres from Miranshah, the main town of North Waziristan, TV channels reported.
Senior Taliban leader Haqqani's residence and madrassa are also located in the Tanda Darpakhel area and it was not immediately clear whether they had been the target of the attack.
Taliban fighters surrounded the area around the madrassa that was attacked and did not allow people to approach the site. North and South Waziristan tribal regions are considered strongholds of the Pakistani Taliban led by Baitullah Mehsud.
Pakistan's tribal belt has witnessed a sharp increase in attacks by drones operated by the US-led coalition forces in Afghanistan over the past week. More than 40 people have died in these attacks.
Twenty people, a majority of them women and children, were killed in a raid at Angoor Adda in South Waziristan by gunship helicopters and commandos of the US-led coalition forces on September 3.
That attack marked the first time that US-led ground forces from Afghanistan had intruded into Pakistan.