Israeli rescue services say around 50 people were seriously injured when their tourist bus overturned near the Red Sea resort town of Eilat.
The rescue services say several people are still trapped inside, but had no immediate word on fatalities. Israel's Channel 10 TV is reporting that several people were killed.
The rescue services say they have sent ambulances to the scene and Israel's air force sent six helicopters.
The accident today took place on a desert road right near Israel's sourthern tip.