Unidentified gunmen shot dead four persons, including a prominent India-born Shia scholar, in this Pakistani port city on Thursday in target killings.
Four gunmen opened fire on an auto-rickshaw in which Allama Taqi Hadi Naqvi was travelling, police said.
Naqvi succumbed to his wounds in hospital, police official Imran Shaukat said.
Renowned within academic circles, Naqvi was born in Moradabad district of India's Uttar Pradesh state and moved to Pakistan with his family after independence.
Three other persons, including the administrator of a madrassa and his son, were shot dead by gunmen in separate incidents in the city.
Karachi, Pakistan's economic hub, has for long been wracked by political, ethnic and sectarian unrest. Militants specially target members of the Shia minority.