Interpol said on Friday it has issued red notices, its top most-wanted alert, for the arrest of the former Libyan strongman Muammar Gaddafi, his son Seif al-Islam and the country's ex-head of military intelligence, Abdullah al-Senoussi.
The move comes in response to a request by the prosecutor of the International Criminal Court, which is seeking the men for alleged crimes against humanity.
Gaddafi hasn't been seen in public for months and went underground after anti-regime fighters swept into Tripoli on August 21.
Interpol said in a statement on Friday it had transmitted the red notices to its 188 member countries. A red notice is the equivalent to being on the Lyon, France-based international police body's most-wanted list.
Friday's statement quotes Interpol Secretary General Ronald K. Noble as calling the notices "a powerful tool" in helping lead to the capture of the Gaddafis and al-Senussi. He added the notices will "significantly restrict the ability of all three men to cross international borders."
The question of Gaddafi's whereabouts has been the subject of extensive speculation in Libya, and rumors have put him everywhere from deep in a bunker under Tripoli to safe in exile in neighboring Niger or Algeria.
On Thursday, Gaddafi himself dismissed talk of his flight, saying in an audio broadcast that he's still in Libya, and exhorting followers to keep fighting.