Afghanistan President Hamid Karzai will on Thursday embark on an official two-day visit to Russia at the invitation of his Russian counterpart, Dmitry Medvedev, the Kremlin press service said.
Talks between the two leaders are to be held on Friday.
Karzai will be accompanied by a delegation of 80 officials, ministers and businessmen.
An agreement on trade and economic cooperation is expected to be signed between the countries.
Karzai earlier said he was looking forward to visiting Moscow to hold talks on bilateral ties, including joint efforts in the fight against drugs and supplying humanitarian aid to Afghanistan.