Kyrgyz Prime Minister Azim Isabekov has resigned, his press office said on Thursday, a move that under the constitution requires the whole cabinet to quit.
"He has offered his resignation himself today," a spokesman for Isabekov said.
Cabinet members could not be reached for comment.
The move came a day after Bakiyev, locked in a dispute with the opposition, rescinded a decision to sack top cabinet officials after his most radical critics snubbed an offer to form a coalition government.
Kyrgyzstan, home to US and Russian military air bases, has been volatile since Bakiyev came to power in 2005 after a wave of violent protests ousted his long-serving predecessor.