Llamas can help fight bio-terrorism: Scientists | world | Hindustan Times
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Llamas can help fight bio-terrorism: Scientists

world Updated: Jan 22, 2010 14:52 IST

Now, llamas can play an important role in the fight against terror, as scientists have developed a way to use the animal's proteins that can detect botulinum neurotoxins (BONTs) -- the deadliest naturally occurring toxins that have potential to be used as bioweapons.

Scientists at Foundation for Biomedical Research (SFBR) in Texas claimed to have developed the BoNT-detecting substances or the antibodies -- proteins made by the body to fight diseases -- found in llamas.

The llama antibodies, called single domain antibodies (sdAb) or "nanobodies," are molecularly flexible, unlike conventional antibodies, ScienceDaily reported.

"As such, sdAb may allow biosensors to be regenerable and used over and over without loss of activity. Also, for some types of BoNT, conventional antibodies are not generally available and we are filling this biosecurity gap," said Andrew Hayhurst, lead researcher and a virologist at the SFBR.

"Since some sdAb have been shown to have inhibitory activity and can block toxin function, they may play a role as part of a future anti-botulism treatment," Hayhurst wrote in his research paper, published in the journal PLoS ONE.

BoNTs, which are about 100 billion times more toxic than cyanide, directly hit the nervous system, resulting in paralysis that can be so severe as to require life support on a mechanical ventilator for weeks to months.

BoNTs are the only toxins in the federal Centers for Disease Control and Prevention's (CDC) 'category A' list of potential bioterror threats alongside anthrax, Ebola virus and other infectious agents.