Now that his re-election is secured, President Barack Obama has a freer hand to deal with a world of familiar problems in fresh ways, from toughening America's approach to Iran and Syria while potentially engaging other repressive countries such as Cuba and North Korea and refocusing on moribund Middle East peace efforts.
The first tweaks in his Iran policy could come within weeks, officials said.
But a pressing task for Obama will be to assign a new team to carry out his national security agenda.
Secretary of state Hillary Rodham Clinton has announced her plans to retire but could stay a few weeks past January to help the administration as it reshuffles personnel.
Defense secretary Leon Panetta is likely to depart shortly after her. CIA Director Gen. David Petraeus is expected to stay on.
The favorite to succeed Clinton, UN ambassador Susan Rice, would face a difficult Senate confirmation process after her much-maligned explanations of the attack on the US consulate in Benghazi, Libya, meaning she could land instead as Obama's national security adviser.
That job that doesn't require the Senate's approval. Tom Donilon, who currently holds that position, and Chuck Hagel, a former Republican senator, are among the other contenders.
The chances of another early favorite, Senate foreign relations committee chairman John Kerry, are hampered by Democrats' fear that Republican Scott Brown, who lost his Massachusetts Senate seat on Tuesday, could win Kerry's seat in a race to replace him. Wall Street reconciles to Obama again
The chances of another early favorite, Senate Foreign Relations Committee Chairman John Kerry, are hampered by Democrats' fear that Republican Scott Brown, who lost his Massachusetts Senate seat Tuesday, could win Kerry's seat in a race to replace him.
Officials, however, are pointing to Jon Huntsman, the former Utah governor, Obama's ambassador to China and Republican presidential candidate, and the state department's current No. 2, William Burns.
Choosing Huntsman would allow the president to claim bipartisanship while putting an Asia expert in the job at a time when the US is focusing more attention on the world's most populous continent.
Burns would be an option as caretaker secretary until postelection passions in Congress subside and a permanent replacement might face smoother confirmation. Economy the single most important issue on agenda
He is a career diplomat who has no political baggage and would be unlikely to stir significant opposition among lawmakers.
At the Pentagon, speculation about successors has been limited.
Panetta's deputy, Ashton Carter, is seen as a possibility, along with Michele Flournoy, who served as defense department policy chief from 2009-12 and would be the first woman in the top job.
New Cabinet members will enter at a time of various global security challenges, from the Arab Spring to China's rapid economic and military expansion in Asia.
But the president's escape from any future campaigning also offers unique diplomatic opportunities, which Obama himself hinted at in March when he told then-Russian president and current prime minister Dmitry Medvedev that he'd have 'more flexibility' on thorny issues after the election. Analysis: Obama's second term to sustain Asia pivot
Obama's immediate predecessors, Bill Clinton and George W. Bush, used their second terms to launch major, though ultimately unsuccessful initiatives for an Israeli-Palestinian accord, an elusive goal that Obama also deeply desires.
This summer he listed the lack of progress toward peace among the biggest disappointments of his presidency so far, suggesting another US attempt in the offing.
Clinton's Camp David negotiations and Bush's Annapolis process became signature foreign policy priorities in 2000 and 2007.
But the Israelis and the Palestinians remain as far apart as ever on the contours of an agreement, from the borders of their two separate states to issues related to refugees and resources.
Obamas's Middle East agenda
Any Obama-led plan for the Middle East will be complicated by Israel's fears about the Iranian nuclear program, civil war in nearby Syria and the new reality of an Islamist-led Egypt having replaced America's most faithful Arab ally.
Obama's difficult relationship with Israeli Prime Minister Benjamin Netanyahu could also complicate the process.
With Iran, the president is holding out hope that crippling economic sanctions will force the Islamic republic's leaders to scale back its uranium enrichment activity.
Iran insists its program is designed for energy and medical research purposes, even as many in the West fear the ultimate goal is to produce nuclear weapons. World shares shed gains made after Obama win
Obama has stressed the narrowing time frame for Tehran to negotiate a peaceful solution to the standoff, while pressing Israel to hold off on any plans for a pre-emptive strike.
Officials say the administration is likely to adjust its two-track approach to Iran — which offers Tehran rewards for coming clean on its nuclear program and harsher penalties for continued defiance — in the coming weeks.
Details are still being debated. In the end, however, Obama may have to resort to a military strategy if Iran continues to enrich uranium at higher levels and nears production of weapons-grade material — a possible scenario he acknowledges.
"The clock is ticking. We're not going to allow Iran to perpetually engage in negotiations that lead nowhere," Obama said in his last foreign policy debate with Republican presidential candidate Mitt Romney.
"We have a sense of when they would get breakout capacity, which means that we would not be able to intervene in time to stop their nuclear program."
Syria's widening conflict is another concern. Full text of Obama's victory speech
More than 36,000 people have died in the last 20 months, as a brutal crackdown on dissent by President Bashar Assad's regime has descended into a full-scale civil war. Obama has demanded Assad's departure, yet has ruled out military assistance to the rebels or American military actions such as airstrikes or enforcing a no-fly zone over Syria.
Last week, in a significant shift in policy, the secretary of state demanded a major shakeup in the opposition's ranks in the hopes of rallying Syrians behind the rebellion.
However, Clinton's spokeswoman, Victoria Nuland, reiterated Wednesday the administration still rejects the notion of providing weapons to anti-Assad fighters or any talk of armed intervention.
In other places, Obama's engagement efforts may get another look. After some success with a rapidly liberalizing Myanmar, there are hopes for democratic reforms and human rights advances in Cuba and North Korea, among others.
But short of a rapid change in attitude from these governments, Obama's options for a landmark breakthrough in US diplomacy are limited.
He won't be able to reach out to Havana until it frees the jailed US contractor Alan Gross, while Pyongyang will have to denuclearize if it wants better relations with America — steps neither regime has shown a willingness to entertain.
The recent re-election of Venezuelan President Hugo Chavez has halted chances for now of any rapprochement between Washington and Caracas. India happy it’s business as usual
In Afghanistan, the president will seek to stick to NATO's 2014 withdrawal date for most international troops, a central campaign promise.
His administration has been trying unsuccessfully to jump-start peace negotiations between President Hamid Karzai's Western-backed government and the Taliban.
The so-called reconciliation effort relies heavily on America's frustrating and unreliable ally Pakistan, where extremist groups such as al-Qaida and the Haqqani network will continue to face US drone attacks.
American geopolitical strategy
Behind all the diplomatic efforts are larger questions of American geopolitical strategy.
Obama had initial success improving US relations with Russia, getting a nuclear arms-reduction pact in 2011, but has since seen America's former Cold War foe frustrate US missile defense plans and hopes of an international consensus on Syria.
The president has continued to trumpet the benefits of his Russia 'reset' policy but may take a firmer stance against Moscow if it refuses to show compromise. Obama set to 'extend hand' to Iran again: analysts
For economic reasons, China policy is less likely to change.
The world's two biggest economies are deeply interdependent and, despite lingering disagreements over Beijing's currency exchange rates and intellectual property infringement, neither side will want to do anything that threatens a trade war and jeopardizes China's booming growth or America's still-fragile jobs recovery.
Obama Asian plans
President Barack Obama's re-election means he can sustain the strategic shift toward the Asia-Pacific started during his first term but the attention and resources the region gets may be hostage to instability in the Middle East and budget battles in Washington.
He is slated to meet a summit of East Asian leaders in Cambodia in November. He could also make a side-trip to Myanmar, becoming the first US president to visit that military-dominated country to reward its democratic reforms.
Many Asian governments are likely to welcome Obama's victory over Republican challenger Mitt Romney.
Concerned about China's rising power and assertive behavior, they have supported the Obama administration's 'pivot' to the region as the US disentangles from the wars in Iraq and Afghanistan.
Still, they also want the US to get along with China, the hub of the Asian economy. China wants new Obama administration to improve ties
Romney's defeat will be greeted with quiet relief in Beijing, which wants stability in its most critical bilateral relationship as it undergoes its own leadership transition that kicks off at a Communist Party Congress on Thursday.
Whether Asia policy gets the kind of attention from the US as during the first term will depend partly on who succeeds secretary of state Hillary Rodham Clinton.
She has made at least a dozen trips to the region and championed the view that US interests lie in more ties with that booming continent.
Stocks plunge after Obama election as Europe woes deepen
US stocks fell more than 2% on Wednesday, putting the S&P 500 on track for its biggest drop since June, as investors shifted their focus to a looming fiscal showdown in Congress after President Barack Obama's re-election. Read more
Energy, healthcare and the banking sectors were among the hardest hit after Obama defeated Republican Mitt Romney, whose policy positions favored those industries. Defense shares also plunged.
The Dow Jones industrial average was down 329.86 points, or 2.49%, at 12,915.82.
The Standard & Poor's 500 Index was down 36.03 points, or 2.52%, at 1,392.36.
The Nasdaq Composite Index was down 76.72 points, or 2.55%, at 2,935.21. The S&P 500 also below the key 1,400 level for the first time since September 4.
(With inputs from AP, AFP and Reuters)