At least 4,525 people have died from swine flu infections since the A(H1N1) virus was uncovered in April, the World Health Organisation said on Friday.
This is an increase of 417 fatal cases from a week ago when 4,108 deaths were recorded, the UN health agency said in its weekly update of the pandemic.
Most deaths occurred in the Americas region, where 3,292 fatalities have been reported. Some 890 people have died from the infection in the Asia-Pacific region, while at least 193 fatal cases have been recorded in Europe.
Eighty deaths have been reported in the Middle East while in Africa, 70 people have succumbed to the disease.