Undeterred by the threats of retaliation from militants, the US intends to step up its drone strikes in Pakistan's tribal areas and may extend them deeper inside the country, a media report said on Tuesday.
On Sunday, a Taliban leader vowed to unleash two suicide attacks a week, similar to Saturday's Islamabad blast, unless the CIA stopped firing missiles in the region.
Pakistani officials have already expressed concern that the missile strikes fuel more violence in the country.
But the New York Times quoted US officials as saying that the plan to intensify missile strikes underscored President Obama's goal to "disrupt, dismantle and defeat" Al-Qaeda in Pakistan and Afghanistan, as well as to strike at other militant groups.
Officials are also proposing to broaden the strikes to Baluchistan, south of the tribal areas, unless Pakistan reduces the incursion of militants there, the report said.
Senator Carl Levin, a Michigan Democrat who heads the Armed Services Committee, acknowledged last week that "the price is very heavy" when missile strikes mistakenly kill civilians, but he said the strikes were" an extremely effective tool".
Some experts have said that a crucial change in aerial warfare, in which US forces are often stalking individuals rather than tanks and other large armaments, has raised new legal issues.