Want to prevent or treat kidney stone? Solution lies in your gut bacteria | Health - Hindustan Times
close_game
close_game

Want to prevent or treat kidney stone? Solution lies in your gut bacteria

ByANI, Washington Dc
Oct 14, 2016 02:22 PM IST

In a recent research, scientists discovered that substance secreted by gut bacteria might help prevent or treat kidney stones.

In a recent research, scientists discovered that substance secreted by gut bacteria might help prevent or treat kidney stones.

Kidney stones can pose serious health problems for people and can increase their risks of developing chronic kidney disease and kidney failure.(Shutterstock)
Kidney stones can pose serious health problems for people and can increase their risks of developing chronic kidney disease and kidney failure.(Shutterstock)

Kidney stones can pose serious health problems for people and can increase their risks of developing chronic kidney disease and kidney failure.

Now catch your favourite game on Crickit. Anytime Anywhere. Find out how

Oxalate is a small anion that can complex with calcium to form calcium oxalate kidney stones under certain conditions and elevated urinary excretion of oxalate can be an indicator of increased risk.

The intestines play a crucial role in oxalate balance and Oxalobacter formigenes (Of) is an anaerobic bacterium that lives in the large intestine and utilizes oxalate as its exclusive energy source.

Expert Hatim Hassan and his team found that factors secreted by Of can stimulate oxalate transport by human intestinal cells grown in tissue culture.

The team also revealed that the mechanisms of the observed stimulation involve the PKA signalling pathway and a protein transporter called SLC26A6.

Importantly, Of factors reduced urinary oxalate excretion by 32.5% in mice by stimulating colonic oxalate secretion.

“Probiotic bacteria have several health benefits; however, the difficulties in determining intestinal bacterial bioavailability and biosafety concerns when administering live probiotics are potential problems facing current probiotics clinical applications. Developing probiotics-derived factors as novel therapeutic agents is an alternative approach that addresses such concerns,” Hassan explained.

In a recent research, scientists discovered that substance secreted by gut bacteria might help prevent or treat kidney stones. (Shutterstock)
In a recent research, scientists discovered that substance secreted by gut bacteria might help prevent or treat kidney stones. (Shutterstock)

Adding, “The fact that these factors retain their biological activity and can effectively reduce urinary oxalate excretion in mice indicates their significant potential as novel therapeutic agents, and provides a compelling reason for the aggressive pursuit of their characterization, which is currently underway.”

The findings appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN).

Get World Cup ready with Crick-it! From live scores to match stats, catch all the action here. Explore now!.

Catch your daily dose of Fashion, Taylor Swift, Health, Festivals, Travel, Relationship, Recipe and all the other Latest Lifestyle News on Hindustan Times Website and APPs.
SHARE THIS ARTICLE ON
SHARE
Story Saved
Live Score
OPEN APP
Saved Articles
Following
My Reads
Sign out
New Delhi 0C
Sunday, June 23, 2024
Start 14 Days Free Trial Subscribe Now
Follow Us On