Female hormone estrogen may not be only cause of Endometriosis: Study
Mumbai city news: Endometriosis is a painful condition, in which a tissue that normally grows in the uterus, grow outside it, often in the ovaries and fallopian tubes.mumbai Updated: Jun 14, 2017 10:53 IST
Female hormone estrogen may not be the only cause of Endometriosis- a common gynecological problem, according to the latest research study conducted by a city-based scientist and his team.
Endometriosis is a painful condition, in which a tissue that normally grows in the uterus, grow outside it, often in the ovaries and fallopian tubes. These tissues thicken, break down and bleed during a woman’s menstrual bleeding, affecting conception.
About 70% of women with endometriosis experience mild to excruciating pelvic pain, depending on the severity. Moreover, it is one of the leading causes of infertility among women in the reproductive age group. It is estimated that 35-50% of women with infertility have endometriosis.
While prior studies have implicated the role of the hormone estrogen in causing endometriosis, its cause is not entirely known, said Dr Deepak Modi, scientist at the National Institute of Research in Reproductive Health, Indian Council of Medical Research (ICMR) Parel, Mumbai who led the study.
“These studies were based on the rationale that as estrogen allows the growth of the normal tissue in the uterus, it must also promote growth of tissue outside as well. So we decided to check if estrogen was actually responsible for growth of uterine tissues in ovaries and fallopian tubes,” said Dr Modi
By studying mice, the scientists found that although estrogen allowed the endometrial tissue to stay for more number of days than the control group, they did not grow. Instead, they started dying even with excess of estrogen said Dr Modi.
“This meant that the other causative factors required for the development of the endometriosis,” he added. The study was published in Journal of Biosciences on May 11 2017.
The study finds importance as most treatments available for endometriosis today are ‘anti-estrogen’ therapies, which don’t work in most cases, according to doctors.
“Our results explain why anti-estrogen therapy doesn’t work and we need to search for newer treatment modalities for endometriosis,” said Modi.