Medics from NMMC Hospital take swab sample for RT-PCR and Rapid Antigen for Covid-19 test of commuters at Vashi Railway Station in Navi Mumbai on Monday.(Bachchan Kumar/HT Photo)
Medics from NMMC Hospital take swab sample for RT-PCR and Rapid Antigen for Covid-19 test of commuters at Vashi Railway Station in Navi Mumbai on Monday.(Bachchan Kumar/HT Photo)

Covid-19 can have impact on heart too, say experts

A US study using MRI found cardiac abnormalities in 78 of 100 patients who had recently recovered from Covid-19, including 12 of 18 asymptomatic patients.
By Sanchita Sharma | Hindustan Times, New Delhi
UPDATED ON DEC 15, 2020 02:30 AM IST

The Covid-19 can damage the heart both directly and indirectly, and lead to complications ranging from inflammation of the heart (myocarditis), injury to heart cells (necrosis), heart rhythm disorders (arrhythmias), heart attack, and muscle dysfunction that can lead to acute or protracted heart failure, experts said.

“Covid-19 is a vascular disease that injures heart cells and muscle. It also leads to the formation of blood clots, both in the microvasculature and large vessels, which can block blood supply to the heart, brain and lungs and lead to stroke, heart attack and respiratory failure,” said Dr Ravi R Kasliwal, chairman of clinical and preventive cardiology department at Medanta -The Medicity Hospital.

Also Read: Few Covid-19 deaths in India’s old-age homes, survey finds

A US study using MRI found cardiac abnormalities in 78 of 100 patients who had recently recovered from Covid-19, including 12 of 18 asymptomatic patients. Sixty patients had ongoing myocardial inflammation consistent with myocarditis, found the study, which was published in the Journal of American Medical Association Cardiology in July.

“Even people with mild disease or no symptoms can develop life-threatening cardiovascular complications. What’s worrying is that this holds true for healthy adults with no pre-existing risk factors, which raise their risk of complications,” said Dr Kasliwal, who recommends that everyone who has recovered from Covid-19 be screened for heart damage

Cardiac trouble
Extensive cardiac involvement is what differentiates Sars-CoV-2, the virus that causes Covid-19, from the six other coronaviruses that cause infection in humans, writes cardiologist Dr Eric J Topol, founder, director and professor of molecular medicine at the Scripps Research Translational Institute in La Jolla, California, in the journal Science.

The four human coronaviruses that cause cold-like symptoms have not been associated with heart abnormalities, though there have been isolated reports linking the Middle East Respiratory Syndrome (MERS) caused by MERS-CoV) with myocarditis, and cardiac disease with the Severe Acute Respiratory Syndrome (SARS) caused by Sars-CoV.

Also Read| ‘Extraordinary uncertainties’: Harvard prof on Covid-19, impact on mental health

Sars-CoV-2 is structurally different from Sars-CoV. “The virus targets the angiotensin-converting enzyme 2 (Ace2) receptor throughout the body, facilitating cell entry by way of its spike protein, along with the cooperation of proteases. The heart is one of the many organs with high expression of Ace2. The affinity of Sars-CoV-2 to Ace2 is significantly greater than that of SARS,” according to Dr Topol.

Topol notes the ease with which Sars-CoV-2 infects heart cells derived from induced pluripotent stem cells (iPSCs) in vitro, leading to a distinctive pattern of heart muscle cell fragmentation evident in autopsy reports. Besides directly infecting heart muscle cells, Sars-CoV-2 also enters and infects the endothelial cells that line the blood vessels to the heart and multiple vascular beds, leading to a secondary immune response. This causes blood pressure dysregulation, and activation of a proinflammatory response leading to a cytokine storm, which is a potentially fatal systemic inflammatory syndrome associated with Covid-19.

Persisting problems

Studies have found that injury to heart cells reflected in blood concentrations of a cardiac muscle-specific enzyme called troponin affects at least one in five hospitalised patients and more than half of those with pre-existing heart conditions, which raises the risk of death. Patients with higher troponin amounts also have high markers of inflammation (including C-reactive protein, interleukin-6, ferritin, lactate dehydrogenase), high neutrophil count, and heart dysfunction, all of which heighten immune response.

“The heightened systemic inflammatory responses and diminished blood supply because of clotting, endotheliitis (blood vessel inflammation), sepsis, or hypoxemia (oxygen deprivation) because of acute lung infection leads to indirect cardiac damage,” said Dr Kasliwal.

The cardiovascular damage associated with Sars-CoV-2 infection can persist beyond recovery. Since the virus affects the heart as much as the respiratory tract, further research is needed to understand why some people are more vulnerable to heart damage than others.

SHARE THIS ARTICLE ON
Close
Senior citizens take part in a digital literacy class by Agewell Foundation. (Sourced)
Senior citizens take part in a digital literacy class by Agewell Foundation. (Sourced)

Elderly make the digital switch during Covid-19 pandemic

By Manoj Sharma, New Delhi
PUBLISHED ON MAR 01, 2021 03:34 AM IST
India has about 104 million people aged above 60 — just a shade below China —according to the 2011 Census. But digital inclusion has been a distant dream for them. The government’s National Digital Literacy Mission (NDLM) aims to empower at least one person per household.
Close
**EDS: TWITTER IMAGE POSTED BY @AAPUttarPradesh ON SUNDAY, FEB. 28, 2021** New Delhi: AAP National Convenor and Delhi CM Arvind Kejriwal addresses during a farmer's rally, in Meerut. (PTI Photo)(PTI02_28_2021_000159B)(PTI)
**EDS: TWITTER IMAGE POSTED BY @AAPUttarPradesh ON SUNDAY, FEB. 28, 2021** New Delhi: AAP National Convenor and Delhi CM Arvind Kejriwal addresses during a farmer's rally, in Meerut. (PTI Photo)(PTI02_28_2021_000159B)(PTI)

Farmers in a do-or-die battle: Kejriwal at mahapanchayat

By S Raju, Meerut
PUBLISHED ON MAR 01, 2021 02:35 AM IST
Speaking at a Kisan Mahapanchayat in Meerut, the Aam Aadmi Party (AAP) leader termed the new laws as a “a death warrant” for farmers. He said the farmers were in a “do or die” battle because they felt the government would hand over their land to corporates and they would become labourers on their own land.
Close
Mehul Choksi siphoned off close to <span class='webrupee'>₹</span>7,080 crore in the <span class='webrupee'>₹</span>13,578 crore Punjab National Bank (PNB) fraud before fleeing to Antigua on January 4, 2018, a month before the mega-scam came to notice.(HT Photo)
Mehul Choksi siphoned off close to 7,080 crore in the 13,578 crore Punjab National Bank (PNB) fraud before fleeing to Antigua on January 4, 2018, a month before the mega-scam came to notice.(HT Photo)

Antigua revokes citizenship of Mehul Choksi

By Neeraj Chauhan, New Delhi
PUBLISHED ON MAR 01, 2021 12:57 AM IST
The development was confirmed to HT by at least two officers in the Central Bureau of Investigation (CBI) and Enforcement Directorate (ED), who added that the fugitive businessman is currently fighting revocation of his citizenship in an Antiguan civil court.
Close
The new rules that will cover over-the-top (OTT) platforms such as Netflix and Hotstar, social media intermediaries such as Facebook and Twitter, and digital news media, were notified by the government on Thursday.
The new rules that will cover over-the-top (OTT) platforms such as Netflix and Hotstar, social media intermediaries such as Facebook and Twitter, and digital news media, were notified by the government on Thursday.

New rules make way for self-regulation: I&B ministry secretary

By Deeksha Bhardwaj, New Delhi
PUBLISHED ON MAR 01, 2021 12:31 AM IST
“There will be no authoritarian process,” information and broadcasting ministry secretary Amit Khare told Hindustan Times. “The regulation system is accountable to the courts. Any misuse of power can be checked.”
Close
After the elephant attacked and killed the man, it moved southwards leaving behind the 2-year-old calf, which is still in the village. (FOREST DEPT).
After the elephant attacked and killed the man, it moved southwards leaving behind the 2-year-old calf, which is still in the village. (FOREST DEPT).

Chhattisgarh man trampled to death while trying to take selfie with an elephant

PUBLISHED ON MAR 01, 2021 12:20 AM IST
  • The kin of the deceased have been given an instant relief amount of 25,000 and the body has been sent for post-mortem.
Close
People above 65 years of age, those with comorbidities, pregnant women and children below 10 years of age should take necessary precautions, the government advised. In picture - people near the Marina beach in Chennai.(ANI)
People above 65 years of age, those with comorbidities, pregnant women and children below 10 years of age should take necessary precautions, the government advised. In picture - people near the Marina beach in Chennai.(ANI)

Tamil Nadu extends Covid-19 lockdown till March 31

By hindustantimes.com | Written by Srivatsan K C, New Delhi
PUBLISHED ON FEB 28, 2021 11:36 PM IST
The state government, in its new order on Sunday, said that the lockdown is being extended to contain the spread of the novel coronavirus effectively and also asked all district administrations to enforce strict Covid-19 appropriate behaviour.
Close
Amravati is under lockdown as Covid-19 cases witnessed a sudden uptick. (ANI)
Amravati is under lockdown as Covid-19 cases witnessed a sudden uptick. (ANI)

Feb spike of Covid-19 in several states: What we know about mutants, variants

By hindustantimes.com | Edited by Poulomi Ghosh
UPDATED ON FEB 28, 2021 11:04 PM IST
Mutations eventually accumulate to generate variants that differ from the original virus more and more.
Close
Teachers cited stress nearly twice as often as insufficient pay as a reason for quitting. (Praful Gangurde/HT Photo)
Teachers cited stress nearly twice as often as insufficient pay as a reason for quitting. (Praful Gangurde/HT Photo)

Stress key reason for teachers to quit job before, during pandemic: Study

ANI, Washington
PUBLISHED ON FEB 28, 2021 10:08 PM IST
Most former teachers went on to take jobs with less or equal pay, with 3 in 10 taking jobs with no health insurance or retirement benefits.
Close
Health ministry on Sunday released a detailed guideline on how to self-register for vaccine on Co-Win app.
Health ministry on Sunday released a detailed guideline on how to self-register for vaccine on Co-Win app.

How to register on Co-Win: Ministry releases step-by-step guideline

By hindustantimes.com | Edited by Poulomi Ghosh
UPDATED ON FEB 28, 2021 11:17 PM IST
Booking once made on Co-Win app can be rescheduled to even a vaccination centre of another city, in case people have to travel between the two doses of vaccination
Close
File photo: National Conference president and former J-K PM Farooq Abdullah. (HT Photo)
File photo: National Conference president and former J-K PM Farooq Abdullah. (HT Photo)

'Congress must unite to defeat ‘divisive’ forces': Farooq Abdullah

UPDATED ON FEB 28, 2021 09:59 PM IST
  • “I want the Congress party to be strong. I want the Congress to unite and fight the divisive forces," he said.
Close
Union Minister for Health &amp; Family Welfare Dr. Harsh Vardhan.(ANI)
Union Minister for Health & Family Welfare Dr. Harsh Vardhan.(ANI)

Health Minister lauds contributions of medical professionals in pandemic

PTI
PUBLISHED ON FEB 28, 2021 09:58 PM IST
He made these remarks at the Global Indian Physicians Congress, organised by the Global Association for Physicians of Indian Origin (GAPIO), through video conference, the ministry said in a statement.
Close
The average voting percentage across all these local bodies together was around 60.26 per cent, it said.(HT Photo )
The average voting percentage across all these local bodies together was around 60.26 per cent, it said.(HT Photo )

Over 60% voter turnout recorded in Gujarat local body polls

PTI, Ahmedabad
PUBLISHED ON FEB 28, 2021 09:24 PM IST
As per the provisional figures, voter turnout of 54.95 per cent across 81 municipalities, 62.41 per cent in 31 district panchayats, and 63.42 per cent in 231 taluka panchayat, was recorded, the State Election Commission (SEC) said.
Close
A farmer sleeps inside a mosquito net during a protest against the new farm laws, at the Singhu border in New Delhi on Sunday. (ANI Photo)
A farmer sleeps inside a mosquito net during a protest against the new farm laws, at the Singhu border in New Delhi on Sunday. (ANI Photo)

Delhi sees 2nd highest mean maximum temperature for Feb since 1901

PTI, New Delhi
PUBLISHED ON FEB 28, 2021 09:09 PM IST
The highest mean maximum temperature recorded for February in Delhi was 29.7 degrees Celsius in 2006, the IMD officials said.
Close
Congress leader Rashid Alvi said that his party will have work round the clock and formulate a strategy in the upcoming polls to fight BJP.(File photo)
Congress leader Rashid Alvi said that his party will have work round the clock and formulate a strategy in the upcoming polls to fight BJP.(File photo)

Appreciating BJP's work ethics, Rashid Alvi says Congress must work 24/7

ANI, New Delhi
PUBLISHED ON FEB 28, 2021 08:59 PM IST
Alvi also commented on Prime Minister Narendra Modi's regret that he could not learn Tamil Nadu, during his monthly radio programme Maan Ki Baat.
Close
A health worker during a dry run for the administration of Covid-19 vaccine.(ANI/ File photo)
A health worker during a dry run for the administration of Covid-19 vaccine.(ANI/ File photo)

News updates from HT: Dry run at 4 govt-run hospitals in Pune tomorrow

PUBLISHED ON FEB 28, 2021 08:56 PM IST
Here are today’s top news, analysis and opinion. Know all about the latest news and other news updates from Hindustan Times.
Close
SHARE
Story Saved
OPEN APP