Atletico Madrid have recorded five Covid-19 positives, including manager Diego Simeone, while Barcelona had three more cases among their players on Thursday, the LaLiga clubs said.
Atleti said Simeone, captain Koke, midfielder Hector Herrera plus forwards Antoine Griezmann and Joao Felix all tested positive for the coronavirus.
"All of them are asymptomatic and isolating at their respective homes, in strict compliance with the health authorities' guidelines," Atletico said in a statement.
Atleti, fifth in LaLiga on 29 points after 18 games, host Rayo Vallecano on Sunday.
Barcelona said midfielder Philippe Coutinho, defender Sergino Dest and winger Ez Abde were the latest players to return positive tests.
The Catalans had already been hit by a number of Covid-19 cases in their squad, with Ousmane Dembele, Samuel Umtiti and Gavi set to miss Sunday's LaLiga trip to Real Mallorca after testing positive.
Clement Lenglet, Dani Alves, Jordi Alba and Alejandro Balde also returned positive tests this week.
"Footballers Sergino Dest, Coutinho and Ez Abde have tested positive for COVID-19. The players are in good health and self-isolating at home. The club has reported the cases to the relevant authorities," Barcelona said in a statement.
Barca, who last played in the league in a 1-1 draw at Sevilla on Dec. 21, are seventh on 28 points from 18 games.
{{/usCountry}}Barca, who last played in the league in a 1-1 draw at Sevilla on Dec. 21, are seventh on 28 points from 18 games.
{{/usCountry}}Real Madrid are also dealing with a Covid-19 outbreak with Serbia forward Luka Jovic testing positive on Thursday, a day after Thibaut Courtois, Federico Valverde, Eduardo Camavinga, Vinicius Jr returned positive tests.
Luka Modric, Rodrygo, Marco Asensio, Gareth Bale, Marcelo, Andriy Lunin, Isco and David Alaba also tested positive earlier this month.
Spain's 14-day infection rate hit a new record of 1,360 cases per 100,000 people on Tuesday, rising from 1,206 cases the previous day and marking a five-fold increase since the beginning of December.
This story has been published from a wire agency feed without modifications to the text.