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Game of Thrones fans rejoice: Real-life dire wolves are back thanks to CRISPR and ancient DNA resurrection

Once thought extinct, real-life dire wolves—famous from Game of Thrones — are back, marking a bold leap in genetics and the science of de-extinction

Published on: Apr 8, 2025, 15:30:59 IST
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Meet Romulus and Remus—the world’s first de-extinct animals, The mythic creatures that roamed Westeros and ancient Earth alike are no longer just a memory. In a remarkable feat of genetic engineering, scientists have recreated the dire wolf — Canis dirus, the same species that inspired Game of Thrones’ iconic House Stark companions.

Romulus and Remus (x.com/  Colossal Biosciences)
Romulus and Remus (x.com/ Colossal Biosciences)
A screenshot from the Game of Thrones

These creatures are not CGI or fantasy fiction. Weighing up to 70 kg with bone-crushing jaws, dire wolves ruled Ice Age America over 10,000 years ago. Now, after years of research, scientists have used ancient DNA and CRISPR technology to revive their genetic lineage. The result: a living hybrid with over 90% of the original dire wolf genome. The team used DNA from a 13,000-year-old tooth and a 72,000-year-old skull.

 
ABOUT THE AUTHOR
Anurag Mehra

Hello, I'm Anurag, a storyteller weaving narratives as a graphic artist and photographer in the world of lifestyle and entertainment. Through my lens, I freeze moments in time, and with pixels as my canvas, I craft visuals that resonate. Join me on this dual creative journey, where photography and graphic art converge to tell compelling stories of our ever-changing world.

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