Manchester United must beat Portsmouth and Arsenal has to beat Bolton to reach the last 16 of the FA Cup.
Chelsea was also drawn at home on Monday and will meet two-time former European champion Nottingham Forest in the fourth round after the League One team beat Charlton 2-0 on Saturday.
It's the second straight round that Manchester United and Arsenal have drawn Premier League opponents. On Saturday, Arsenal beat defending champions Liverpool 3-1 at Anfield, and the Red Devils won 2-1 over Aston Villa at Old Trafford on Sunday.
The only other certain topflight pairing is West Ham vs Watford. Both teams are in the relegation zone of the Premier League.
Six Premier League teams -- Liverpool, Everton, Villa, Charlton, Sheffield United and Wigan -- were knocked out in the third round and six more still aren't sure of places in the fourth round.
The draw also means it's guaranteed that six of the 16 teams in the fifth round will be from outside the Premier League.