Covid-19 may trigger new diabetes: Experts

Covid-19 may trigger the onset of diabetes in healthy people, and also cause severe complications in diabetic patients, according to an international group of 17 leading experts in the chronic condition.
Based on clinical observations made so far, Stephanie A. Amiel from King’s College London in the UK, said there is a bi-directional relationship between Covid-19 and diabetes.(REUTERS)
Based on clinical observations made so far, Stephanie A. Amiel from King’s College London in the UK, said there is a bi-directional relationship between Covid-19 and diabetes.(REUTERS)
Updated on Jun 16, 2020 10:45 AM IST
Copy Link
London | ByPress Trust of India | Posted by : Jasra Afreen

Covid-19 may trigger the onset of diabetes in healthy people, and also cause severe complications in diabetic patients, according to an international group of 17 leading experts in the chronic condition.Based on clinical observations made so far, the scientists, including Stephanie A. Amiel from King’s College London in the UK, said there is a bi-directional relationship between Covid-19 and diabetes.

In a letter published in the New England Journal of Medicine, they explained that diabetes, on the one hand, is associated with increased risk of Covid-19 severity and mortality with 20 to 30 per cent of patients who died with the infectious disease reported to have diabetes. On the other hand, the researchers said new-onset diabetes and atypical metabolic complications of pre-existing diabetes -- including life-threatening ones -- have been observed in people with Covid-19.

However, they said it is still unclear how SARS-Cov-2, the virus that causes Covid-19, impacts diabetes. Earlier studies had shown that the protein ACE-2 which binds to SARS-Cov-2 and allows the virus to enter human cells is not only located in the lungs, but also in organs and tissues involved in glucose metabolism such as the pancreas, the small intestine, the fat tissue, the liver and the kidney.

According to the researchers, by entering these tissues, the virus may cause multiple and complex dysfunctions of glucose metabolism. The scientists believe it is possible that the novel coronavirus may alter glucose metabolism that could complicate the condition of pre existing diabetes or lead to new mechanisms of disease.

Based on previous research, they said virus infections can also precipitate type 1 diabetes - a chronic condition in which the pancreas produces little or no insulin.

“Diabetes is one of the most prevalent chronic diseases and we are now realising the consequences of the inevitable clash between two pandemics,” said Francesco Rubino, Professor of Metabolic Surgery at King’s College London. However, given the short period of human contact with this new coronavirus, the exact mechanism by which the virus influences glucose metabolism is still unclear, the scientists said.

“We don’t know whether the acute manifestation of diabetes in these patients represent classic type 1, type 2 or possibly a new form of diabetes,” Rubino added. “We don’t yet know the magnitude of the new onset diabetes in Covid-19 and if it will persist or resolve after the infection, and if so, whether or not or Covid-19 increases risk of future diabetes,” said Paul Zimmet, Professor of Diabetes at Monash University in Melbourne.

According to the researchers, assessing routinely collected clinical data can help examine insulin secretory capacity, insulin resistance, and autoimmune antibody status to understand how Covid-19 related diabetes develops, its natural history, and best management. “We are calling on the international medical community to rapidly share relevant clinical observations that can help answer these questions,” Zimmet said.

SHARE THIS ARTICLE ON
Close Story
QUICKREADS

Less time to read?

Try Quickreads

  • G7 leaders during a working lunch to discuss shaping the global economy at Schloss Elmau in Kuren, Germany, on Sunday. 

    G7 leaders mock Putin in jokes about stripping off

    World leaders mocked Russian President Vladimir Putin's tough-man image at a G7 lunch in Germany on Sunday, joking about whether they should strip down to shirtsleeves -- or even less. "Jackets on? Jackets off? Do we take our coats off?" The leaders -- from Britain, Canada, France, Germany, Italy, Japan, the United States and the European Union -- pondered the dilemma. British Prime Minister Boris Johnson interjected: "We've got to show them our pecs."

  • Police are seen outside a township pub in South Africa's southern city of East London.

    At least 20 dead in South African club; cause not yet known

    South African police are investigating the deaths of at least 20 people at a nightclub in the coastal town of East London early Sunday. “At this point we cannot confirm the cause of death,” said health department spokesperson Siyanda Manana. Police Minister Bheki Cele was on Sunday morning expected to visit the scene. The owner of the club, Siyakhangela Ndevu, told local broadcaster eNCA that he had been called to the scene early Sunday morning.

  • France was one of several US allies to condemn the decision, with President Emmanuel Macron denouncing a threat to women’s freedom.

    US Supreme Court decision spurs French government into action

    Politicians representing a parliamentary majority on Saturday voiced support for a bill enshrining abortion rights in France's constitution, after the US Supreme Court revoked the nationwide legal protection for American people to terminate pregnancies. The landmark ruling by the conservative-majority court on Friday overturned almost five decades of constitutional protections for abortion in the United States, allowing individual states to regulate the procedure. Prime Minister Elisabeth Borne said the government would support the bill “wholeheartedly”.

  • President Joe Biden speaks and formally launches the global infrastructure partnership, on the margins of the G7 Summit in Elmau, Germany.

    G7 unveils rival to China’s BRI

    US President Joe Biden announced on Sunday a G7 project to rival China's Belt and Road Initiative by raising some $600 billion for global infrastructure programmes in poor countries. “Together with G7 partners, we aim to mobilise $600 billion by 2027 in global infrastructure investments,” the White House said shortly ahead of a speech by Biden unveiling the proposal.

  • Foreign currency exchange rates for US dollars, Russian rubles and British pounds displayed outside an exchange bureau in Riga, Latvia.

    Russia slides towards default as payment deadline expires

    Russia edged closer to default on Sunday amid little sign that investors holding its international bonds had received payment, heralding what would be the nation's first default in decades. It's largely a symbolic development for now, given that Russia is already an economic, financial and political outcast across most of the world. For Russia, it will mark its first foreign default since the Bolshevik repudiation of Czarist-era debts in 1918.

SHARE
Story Saved
×
Saved Articles
Following
My Reads
Sign out
New Delhi 0C
Monday, June 27, 2022