The 30-share index, which remained firm in the last two trading session and closed higher by 460 points on Tuesday, fell by 267.25 points at 10,416.14 on fresh selling by funds.
Tracking weak global trend, the Bombay Stock Exchange benchmark Sensex lost over 267 points in opening trade on Wednesday on fresh selling by funds.
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The 30-share index, which remained firm in the last two trading session and closed higher by 460 points on Tuesday, fell by 267.25 points at 10,416.14.
The wide-based National Stock Exchange's Nifty also plunged by 77 points at 3,157.90 as most of the participants traded lower.
Marketmen said weakening trend in global markets mainly influenced the trading sentiments in Mumbai.