ICMR has successfully completed clinical trials of the first-ever male contraceptive.(HT File)
ICMR has successfully completed clinical trials of the first-ever male contraceptive.(HT File)

India closer to world’s first male contraceptive injection

The contraceptive is effective for 13 years, after which it loses its potency. It is designed as a replacement for surgical vasectomy, which is the only male sterilisation method available in the world.
By Rhythma Kaul | Hindustan Times, New Delhi
UPDATED ON NOV 19, 2019 07:05 AM IST

The Indian Council of Medical Research (ICMR) has successfully completed clinical trials of the world’s first injectable male contraceptive, which has been sent to the Drug Controller General of India (DCGI) for approval, according to researchers involved in the project.

The contraceptive is effective for 13 years, after which it loses its potency. It is designed as a replacement for surgical vasectomy, which is the only male sterilisation method available in the world.

“The product is ready, with only regulatory approvals pending with the Drugs Controller. The trials are over, including extended, phase 3 clinical trials for which 303 candidates were recruited with 97.3% success rate and no reported side-effects. The product can safely be called the world’s first male contraceptive,” said Dr RS Sharma, senior scientist with ICMR, who has been spearheading the trials.

ICMR is the apex body in India for biomedical research. It is funded by the Indian government through the department of medical research at the Union ministry of health and family welfare.

While researchers in the US were working on a similar contraceptive, it is still under development.

According to an article published on the website of the UK’s National Health Service, a trial for the male contraceptive was conducted in 2016 but it had to be stopped because of side effects. “Side effects like acne and mood changes were common,” it said.

In India, 53.5% of couples use some method of contraception or spacing methods, with permanent methods like sterilisation being the most popular, shows data from the National Family Health Survey-4 (2015-16). Around 36% of women opt for sterilisation as compared to 0.3% men going for vasectomy.

The contraceptive is a polymer that has to be injected under local anaesthesia in the sperm-containing tube near the testicles (vas deferens) by a registered medical professional.

“The polymer was developed by Prof SK Guha from the Indian Institute of Technology in the 1970s. ICMR has been researching on it to turn it into a product for mass use since 1984, and the final product is ready after exhaustive trials,” said Sharma.

The product, called reversible inhibition of sperm under guidance (RISUG), is made of a compound called Styrene Maleic Anhydride. “It is effective for at least 13 years once injected. In clinical studies on mice, it has been proven to be a reliable spacing method, and we will be initiating human studies soon to prove that in humans also, it can be used as an effective spacing method,” said Sharma.

“It’s the first in the world from India so we have to be extra careful about approval. We are looking at all aspects, especially the good manufacturing practice (GMP) certification that won’t raise any questions about its quality,” said VG Somani, the drug controller general of India.

“I’d say it will still take about six to seven months for all the approvals to be granted before the product can be manufactured,” said Sonami. The manufacture, sale and distribution of new medical innovation in India requires approval from DCGI, which conducts its own checks before clearing it.

Doctors say injectable male contraceptives will be preferred over vasectomy. “Non-surgical procedures are always preferred over surgical procedures because they will be safer and less invasive. More men are likely to opt for it,” said Dr Anup Kumar, head of urology and renal transplant department, Safdarjung Hospital.

Experts say a male contraceptives can work well in the Indian context provided the government publicises it proactively.

“Two things are needed from the government for it to work; one is to make use of the trial subjects for awareness generation among masses about the product, and second is to offer higher incentives for people opting for male contraceptives,” says AR Nanda, former family welfare secretary, Government of India.

SHARE THIS ARTICLE ON
Topics
Close
Covid-19 vaccines will be administered on all working days by trained healthcare workers inside the Parliament complex. (REUTERS PHOTO).
Covid-19 vaccines will be administered on all working days by trained healthcare workers inside the Parliament complex. (REUTERS PHOTO).

Vaccination centre for eligible MPs set up inside Parliament complex

PUBLISHED ON MAR 06, 2021 08:03 PM IST
  • Nearly half or 366 out of 777 MPs are eligible for Covid-19 vaccines in the category of elderly people. 47% of MPs are above sixty years of age and meet the criteria for elderly people who can get vaccinated in the current phase.
Close
A nurse prepares to administer a shot of the Covishield COVID-19 vaccine at Sola Civil hospital in Ahmedabad, India, Wednesday, March 3, 2021. The COVID-19 vaccination drive for senior citizens and those above 45 years of age with comorbidities began in government and designated private hospitals in Gujarat on Monday along with the rest of the country. (AP Photo/Ajit Solanki)(AP)
A nurse prepares to administer a shot of the Covishield COVID-19 vaccine at Sola Civil hospital in Ahmedabad, India, Wednesday, March 3, 2021. The COVID-19 vaccination drive for senior citizens and those above 45 years of age with comorbidities began in government and designated private hospitals in Gujarat on Monday along with the rest of the country. (AP Photo/Ajit Solanki)(AP)

Covid-19 vaccination for veterans to begin at service hospitals next week: Army

By HT Correspondent, New Delhi
UPDATED ON MAR 06, 2021 07:49 PM IST
  • There are more than 3.2 million ex-servicemen (ESM) in the country, and many of them have been waiting to get vaccinated at service hospitals.
Close
A nurse prepares to administer a shot of the Covishield COVID-19 vaccine at Sola Civil hospital in Ahmedabad, India, Wednesday, March 3, 2021. The COVID-19 vaccination drive for senior citizens and those above 45 years of age with comorbidities began in government and designated private hospitals in Gujarat on Monday along with the rest of the country. (AP Photo/Ajit Solanki)(AP)
A nurse prepares to administer a shot of the Covishield COVID-19 vaccine at Sola Civil hospital in Ahmedabad, India, Wednesday, March 3, 2021. The COVID-19 vaccination drive for senior citizens and those above 45 years of age with comorbidities began in government and designated private hospitals in Gujarat on Monday along with the rest of the country. (AP Photo/Ajit Solanki)(AP)

Gujarat health official tests positive for Covid-19 after two doses of vaccine

PTI, Ahmedabad
PUBLISHED ON MAR 06, 2021 07:27 PM IST
The health officer in Gandhinagar's Dehgam taluk, had taken the first dose on January 16 and the second one on February 15.
Close
Farmers sitting near their tractor as they take part in a road blockade to mark the 100th day of the protest against the new farm laws on a highway near Kundli Border on Saturday. (ANI Photo)
Farmers sitting near their tractor as they take part in a road blockade to mark the 100th day of the protest against the new farm laws on a highway near Kundli Border on Saturday. (ANI Photo)

Protesting farmers block expressway in Haryana as agitation completes 100th day

Posted by Harshit Sabarwal | PTI
PUBLISHED ON MAR 06, 2021 07:20 PM IST
The road blockade began at 11 am and continued till 4 pm. Farmers holding black flags and wearing black armbands and some women protesters with black 'dupattas' shouted slogans against the BJP-led government for not acceding to their demands.
Close
Himachal Pradesh Chief Minister Jai Ram Thakur presents the budget of the state for the year 2021-22 in the assembly in Shimla on March 6, 2021. (ANI Photo)
Himachal Pradesh Chief Minister Jai Ram Thakur presents the budget of the state for the year 2021-22 in the assembly in Shimla on March 6, 2021. (ANI Photo)

Himachal Pradesh budget 'directionless', says Congress

Posted by Harshit Sabarwal | PTI
PUBLISHED ON MAR 06, 2021 07:10 PM IST
Leader of Opposition Mukesh Agnihotri said the budget presented in the state Assembly was a "half-baked document" in which false promises had been made to the people of the state.
Close
Shortly before midnight, the Senate began to take up a variety of amendments in rapid-fire fashion.(AP)
Shortly before midnight, the Senate began to take up a variety of amendments in rapid-fire fashion.(AP)

Senate works through night with virus aid on path to passage

AP, Washington
PUBLISHED ON MAR 06, 2021 06:44 PM IST
The bill then would return to the House, which was expected to give it final congressional approval and send it to Biden to sign.
Close
Uttar Pradesh Chief Minister Yogi Adityanath.
Uttar Pradesh Chief Minister Yogi Adityanath.

Adityanath meets farmers from western UP, says laws will double their income

ANI, Lucknow
PUBLISHED ON MAR 06, 2021 06:31 PM IST
According to a statement by the state government, the members of the delegation said the agricultural laws implemented by the central government are farmer-friendly.
Close
In all, 3,500 people were accused by the CBI in different cases.(AFP File)
In all, 3,500 people were accused by the CBI in different cases.(AFP File)

CBI launches probe into smuggling of rotten betel nuts to India

By Neeraj Chauhan
PUBLISHED ON MAR 06, 2021 06:25 PM IST
  • The agency has registered a First Information Report (FIR) naming unknown officials of Central Excise and Customs and unknown private persons for causing huge losses adding up to several hundred crores to the government exchequer.
Close
High security outside Antilia at Altamont road after a car laden with gelatin sticks has been found abandoned near billionaire Mukesh Ambani's Antilia residence in Mumbai on Friday. (ANI Photo)
High security outside Antilia at Altamont road after a car laden with gelatin sticks has been found abandoned near billionaire Mukesh Ambani's Antilia residence in Mumbai on Friday. (ANI Photo)

Oppn questions probe into death of 'owner' of vehicle found near Ambani's house

Posted by Shivani | PTI, Mumbai
PUBLISHED ON MAR 06, 2021 06:18 PM IST
Shiv Sena leader and Rajya Sabha member Sanjay Raut said the Sena-led Maharashtra government should not be put in the dock over the death of a prime witness, but finding out the truth was imporant for the coalition government's image.
Close
Union minister Smriti Irani addresses a press conference, in New Delhi.(PTI)
Union minister Smriti Irani addresses a press conference, in New Delhi.(PTI)

Smriti Irani attacks Rahul Gandhi, accuses him of 'insulting' people of Amethi

PTI, Amethi
PUBLISHED ON MAR 06, 2021 05:59 PM IST
Smriti Irani attacks Rahul Gandhi, accuses him of 'insulting' people of Amethi
Close
Aurangabad has added 1,737 fresh cases to the overall tally since March 1 and a total of 17 patients have succumbed to the disease in the same period.(HT file photo)
Aurangabad has added 1,737 fresh cases to the overall tally since March 1 and a total of 17 patients have succumbed to the disease in the same period.(HT file photo)

Aurangabad officials mull lockdown as Covid-19 cases continue to rise

By hindustantimes.com | Written by Shivani, Hindustan Times, New Delhi
UPDATED ON MAR 06, 2021 05:52 PM IST
  • Aurangabad has a total caseload of 52,103 infections while the death toll stands at 1,284. On Friday, the district added 459 cases to the overall state tally.
Close
"Accelerate vaccination for priority population groups in districts reporting higher cases," the ministry said.(Reuters)
"Accelerate vaccination for priority population groups in districts reporting higher cases," the ministry said.(Reuters)

Centre asks states witnessing spike in Covid-19 cases to accelerate vaccination

PTI, New Delhi
UPDATED ON MAR 06, 2021 05:30 PM IST
In a meeting held on Saturday, they have been asked to collaborate with private hospitals to open up vaccination time-table for a minimum of 15 days and maximum of 28 days at a time.
Close
The SP said the victim's brother-in-law got her married to a man in Ghazipur district, but after 10 years, when her husband came to know that she was raped, he divorced her and she returned to Udhampur.(Representational )
The SP said the victim's brother-in-law got her married to a man in Ghazipur district, but after 10 years, when her husband came to know that she was raped, he divorced her and she returned to Udhampur.(Representational )

Raped 27 yrs ago, woman lodges complaint after son asks father's name

PTI, Shahjahanpur
PUBLISHED ON MAR 06, 2021 05:20 PM IST
One Naki Hasan of her locality had entered the house when she was alone and allegedly raped her, Superintendent of Police (City) Sanjay Kumar told PTI on Saturday.
Close
A top official of the state's home department had said on Friday that 16 people from Myanmar have crossed over to India over the last few days, of which 11 have claimed that they were police personnel. (Representative Image)(REUTERS)
A top official of the state's home department had said on Friday that 16 people from Myanmar have crossed over to India over the last few days, of which 11 have claimed that they were police personnel. (Representative Image)(REUTERS)

Myanmar asks Mizoram govt to handover eight cops who fled country

PTI
PUBLISHED ON MAR 06, 2021 05:10 PM IST
Mizoram shares a 510-km-long porous border with Myanmar, where mass demonstrations are being held in protest against the declaration of a year-long emergency by the country's armed forces.
Close
Due to an improvement in the overall situation, authorities allowed for the reopening of colleges, universities and schools for Classes 9 to 12 in January this year with all Covid-related norms in place. (Representative Image) (Raj K Raj/ Hindustan Times)
Due to an improvement in the overall situation, authorities allowed for the reopening of colleges, universities and schools for Classes 9 to 12 in January this year with all Covid-related norms in place. (Representative Image) (Raj K Raj/ Hindustan Times)

News updates from HT: Rajasthan schools, colleges to close due to Covid surge

By hindustantimes.com, Hindustan Times, New Delhi
UPDATED ON MAR 06, 2021 04:54 PM IST
Here are today’s top news, analysis and opinion. Know all about the latest news and other news updates from Hindustan Times.
Close
SHARE
Story Saved
OPEN APP