Longer study breaks lead to more stable activation patterns in brain: Study

Why is taking long breaks while studying so beneficial for our memory? It is generally thought that during learning, neurons are activated and form new connections. In this way, the learned knowledge is stored and can be retrieved by reactivating the same set of neurons.

Many of us have experienced the following: the day before an exam, we try to cram a huge amount of information into our brain. But just as quickly as we acquired it, the knowledge we have painstakingly gained is gone again.

With expanded time intervals between individual learning events, we retain the knowledge for a longer time. (Unsplash)

The good news is that we can counteract this forgetting. With expanded time intervals between individual learning events, we retain the knowledge for a longer time.

But what happens in the brain during the spacing effect, and why is taking breaks so beneficial for our memory? It is generally thought that during learning, neurons are activated and form new connections. In this way, the learned knowledge is stored and can be retrieved by reactivating the same set of neurons.

However, we still know very little about how pauses positively influence this process- even though the spacing effect was described more than a century ago and occurs in almost all animals.

Annet Glas and Pieter Goltstein, neurobiologists in the team of Mark Hubener and Tobias Bonhoeffer, investigated this phenomenon in mice. To do this, the animals had to remember the position of a hidden chocolate piece in a maze.

During the maze test, the researchers additionally measured the activity of neurons in the prefrontal cortex. This brain region is of particular interest for learning processes, as it is known for its role in complex thinking tasks. Accordingly, the scientists showed that inactivation of the prefrontal cortex impaired the mice's performance in the maze.

"If three learning phases follow each other very quickly, we intuitively expected the same neurons to be activated," Pieter Goltstein said. "After all, it is the same experiment with the same information. However, after a long break, it would be conceivable that the brain interprets the following learning phase as a new event and processes it with different neurons."

However, the researchers found exactly the opposite when they compared the neuronal activity during different learning phases. After short pauses, the activation pattern in the brain fluctuated more than compared to long pauses: In fast successive learning phases, the mice activated mostly different neurons. When taking longer breaks, the same neurons active during the first learning phase were used again later.

Reactivating the same neurons could allow the brain to strengthen the connections between these cells in each learning phase - there is no need to start from scratch and establish the contacts first. "That's why we believe that memory benefits from longer breaks," said Pieter Goltstein.

Thus, after more than a century, the study provides the first insights into the neuronal processes that explain the positive effect of learning breaks. With spaced learning, we may reach our goal more slowly, but we benefit from our knowledge for much longer. Hopefully, we won't have forgotten this by the time we take our next exam!