Dr Anthony Fauci, an infectious disease expert who is the chief medical adviser to U.S. President Joe Biden, will retire by the end of Biden's term, he told Politico in an interview on Monday.
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Fauci, 81, has been the director of the National Institute of Allergy and Infectious Diseases (NIAID) since 1984 and became the face of the US government's efforts to contain the Covid-19 pandemic.
He served on the White House coronavirus task force under former President Donald Trump.
NIAID did not immediately respond to a Reuters request for comment.
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