Ceftizoxime is a third generation cephalosporin that is used in the treatment of meningitis & other diseases.health and fitness Updated: Feb 09, 2004 20:43 IST
Systems: General (Systemic)
Category: Third Generation Cephalosporin
Ceftizoxime is given parenterally. It is not metabolised in the body and is excreted through the kidneys. Plasma half life is 1.5-2 hours.
Ceftizoxime is a third generation cephalosporin that is used in the treatment of meningitis, intra-abdominal infections, respiratory infections, skin and soft tissue infections, bone and joint infections, obstetric and gynaecological infectins. It is active against aerobic gram negative bacteria and some gram gram positive bacteria. Not very active against bacteroides,pseudomonas and staph.aureus.
Routes of Administration and Dosage
For bacterial infections: For injection dosage form in Adults : 0.5 -1 gms I.M or I.V every eight to twelve hours.
Ceftizoxime is contraindicated in renal disease, pregnancy, lactation, infants less than one month of age, and hypersensitivity .
Precautions are to be taken in renal failure, hypersensitivity to penicillins, and pseudomembranous colitis.
Probenicid reduces the renal clearance of Ceftizoxime. Chlorampenicol reduces the drug's activity.
Cefizox(Burroughs Wellcome), Epocelin(Rallis).