Fight against malaria: New antibody may result in better prevention measures

Malaria kills about 445,000 people a year, mostly young children in sub-Saharan Africa, and sickens more than 200 million, researchers said.

Scientists have found a human antibody that prevented malaria infection in mice by binding a protein found in almost all the strains of the parasite worldwide. The human antibody was isolated from a protected subject who received an experimental vaccine containing whole, weakened malaria parasites (PfSPZ Vaccine-Sanaria).

The paired findings - of both the antibody and the site it targets on the surface protein - could open new pathways to malaria prevention, researchers at the National Institutes of Health in the US. The study, published in the journal Nature Medicine, shows that the antibody, called CIS43, protects against malaria better than any antibody that has been described before.

If shown to be effective in humans, the antibody could be given to people directly and potentially protect them from malaria for up to six months, said Marie Pancera from Fred Hutchinson Cancer Research Center. Preventive malaria drugs available now must be taken daily, researchers said. What especially interests Pancera is whether researchers could use the unique binding site identified in the study, on the surface protein known as circumsporozoite protein, or CSP, to design a vaccine that could tickle the immune system to produce such antibodies.

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