Myeloid leukemias are cancers derived from stem and progenitor cells in the bone marrow that give rise to all normal blood cells.(Unsplash)
Myeloid leukemias are cancers derived from stem and progenitor cells in the bone marrow that give rise to all normal blood cells.(Unsplash)

New class of drugs to treat blood and bone marrow cancers: Research

A group of scientists in the US, including an Indian-American from the prestigious Cleveland Clinic, have identified a potential new class of drugs that may prove effective in treating certain common types of blood and bone marrow cancers.
By Press Trust of India | Posted by Jahnavi Gupta | Washington
UPDATED ON DEC 26, 2020 05:04 PM IST

A group of scientists in the US, including an Indian-American from the prestigious Cleveland Clinic, have identified a potential new class of drugs that may prove effective in treating certain common types of blood and bone marrow cancers.

First published in the latest edition of Blood Cancer Discovery, the decade long research which reports that a new pharmacological strategy to preferentially target and eliminate leukemia cells with TET2 mutations, was carried out by Jaroslaw Maciejewski and his collaborator Babal Kant Jha from the Cleveland Clinic Department of Translational Hematology & Oncology Research.

Myeloid leukemias are cancers derived from stem and progenitor cells in the bone marrow that give rise to all normal blood cells.

One of the most common mutations involved in driving myeloid leukemias are found in the TET2 gene, which has been investigated for the last decade by Maciejewski and Jha.

“In preclinical models, we found that a synthetic molecule called TETi76 was able to target and kill the mutant cancer cells both in the early phases of disease--what we call clonal hematopoiesis of indeterminate potential, or CHIP--and in fully developed TET2 mutant myeloid leukemia,” said Dr Maciejewski.

According to a media release, the research team designed TETi76 to replicate and amplify the effects of a natural molecule called 2HG (2-hydroxyglutarate), which inhibits the enzymatic activity of TET genes.

The TET DNA dioxygenase gene family codes for enzymes that remove chemical groups from DNA molecules, which ultimately changes what genes are expressed and can contribute to the development and spread of disease.

While all members of the TET family are dioxygenases, the most powerful enzymatic activity belongs to TET2, the press release said.

Even when TET2 is mutated, however, its related genes TET1 and TET3 provide residual enzymatic activity. While significantly less, this activity is still enough to facilitate the spread of mutated cancer cells.

Maciejewski’s and Jha’s new pharmacologic strategy to selectively eliminate TET2 mutant leukemia cells centers on targeting their reliance on this residual DNA dioxygenase activity, it said.

“We took lessons from the natural biological capabilities of 2HG,” explained Jha, a principal investigator.

“We studied the molecule and rationally designed a novel small molecule, synthesized by our chemistry group headed by James Phillips, PhD. Together, we generated TETi76–a similar, but more potent version capable of inhibiting not just TET2, but also the remaining disease-driving enzymatic activity of TET1 and TET3,” Jha said.

Cleveland Clinic said that the researchers studied TETi76’s effects in both preclinical disease and xenograft models (where human cancer cells are implanted into preclinical models). Additional studies will be critical to investigate the small molecule’s cancer-fighting capabilities in patients.

“We are optimistic about our results, which show not just that TETi76 preferentially restricts the growth and spread of cells with TET2 mutations, but also gives survival advantage to normal stem and progenitor cells,” Jha said.

(This story has been published from a wire agency feed without modifications to the text.)

Follow more stories on Facebook and Twitter

SHARE THIS ARTICLE ON
app
Close
Ananya Panday's new fitness post has our mind blown(Instagram/anshukayoga and ananyapanday)
Ananya Panday's new fitness post has our mind blown(Instagram/anshukayoga and ananyapanday)

Ananya Panday does inverted butterfly pose after 108 Surya Namaskars in new post

By Nishtha Grover, Delhi
PUBLISHED ON JAN 24, 2021 07:45 PM IST
  • Ananya Panday loves an intense morning Yoga session. The actor has lately been sharing a lot of aerial Yoga posts on social media and blowing our minds away.
Close
Social influence has a large impact on people's adherence to Covid-19 guidelines, suggest the findings of a new study.(ANI)
Social influence has a large impact on people's adherence to Covid-19 guidelines, suggest the findings of a new study.(ANI)

When it comes to following Covid-19 guidelines, social influence matters

ANI
PUBLISHED ON JAN 24, 2021 06:13 PM IST
Social influence has a large impact on people's adherence to Covid-19 guidelines, suggest the findings of a new study.
Close
Antidepressants do not work for back pain, osteoarthritis(Unsplash)
Antidepressants do not work for back pain, osteoarthritis(Unsplash)

Antidepressants won't help with back pain and osteoarthritis, says study

ANI, Canberra
PUBLISHED ON JAN 24, 2021 01:38 PM IST
A recent study suggested that contrary to the common belief stimulant medication does not have any effect on chronic back pain and hip and knee osteoarthritis.
Close
Jacqueline Fernandez shares favourite workout, fitness goals for 2021 | Watch(Instagram/jacquelinef143)
Jacqueline Fernandez shares favourite workout, fitness goals for 2021 | Watch(Instagram/jacquelinef143)

Jacqueline Fernandez shares favourite workout, fitness goals for 2021 | Watch

By Zarafshan Shiraz
UPDATED ON JAN 24, 2021 01:35 PM IST
  • From sharing the best fitness advice she has ever received, to her goals for 2021, favourite way to workout and more, Jacqueline Fernandez reveals some health and wellness tips in this viral video
Close
People who recover from Covid-19 are protected against the novel coronavirus for at least six months, and likely much longer, according to a study which says the immune system evolves long after the infection and may block even mutant forms of the virus such as the South African variant.(Yahoo)
People who recover from Covid-19 are protected against the novel coronavirus for at least six months, and likely much longer, according to a study which says the immune system evolves long after the infection and may block even mutant forms of the virus such as the South African variant.(Yahoo)

Immune system of recovered Covid-19 patients may fight coronavirus variants

PTI
PUBLISHED ON JAN 24, 2021 11:23 AM IST
People who recover from Covid-19 are protected against the novel coronavirus for at least six months, and likely much longer, according to a study which says the immune system evolves long after the infection and may block even mutant forms of the virus such as the South African variant.
Close
A new study has found that gene-editing techniques like CRISPR-Cas hold the power to rectify inherited retinal degenerative mutations, which are the primary cause of blindness.(ANI)
A new study has found that gene-editing techniques like CRISPR-Cas hold the power to rectify inherited retinal degenerative mutations, which are the primary cause of blindness.(ANI)

Gene editing techniques helpful in retinal degeneration treatment

ANI
PUBLISHED ON JAN 24, 2021 10:43 AM IST
A new study has found that gene-editing techniques like CRISPR-Cas hold the power to rectify inherited retinal degenerative mutations, which are the primary cause of blindness.
Close
A team of researchers from China considers a pseudoaneurysm with median nerve injury caused by right radial artery puncture.(ANI)
A team of researchers from China considers a pseudoaneurysm with median nerve injury caused by right radial artery puncture.(ANI)

Pseudoaneurysm with median nerve injury caused by right radial artery puncture

ANI
PUBLISHED ON JAN 24, 2021 09:34 AM IST
A team of researchers from China considers a pseudoaneurysm with median nerve injury caused by right radial artery puncture.
Close
Representational image(Unsplash)
Representational image(Unsplash)

Even one alcoholic drink per day can increase risk of atrial fibrillation

ANI
PUBLISHED ON JAN 23, 2021 10:47 PM IST
A recent study revealed that individuals who regularly drink a humble measure of liquor are at a higher risk of atrial fibrillation, a condition where the heart pulsates in a strange rhythm.
Close
Representational image(Unsplash)
Representational image(Unsplash)

Coffee temporarily counteracts effect of sleep loss on cognitive function: Study

ANI
PUBLISHED ON JAN 23, 2021 10:36 PM IST
Consuming caffeinated coffee during the day helps to minimise reductions in attention and cognitive function, compared to decaffeinated coffee, suggest the findings of a new study.
Close
Representational Image(Unsplash)
Representational Image(Unsplash)

Here's how eating habits could cause child obesity

ANI
PUBLISHED ON JAN 23, 2021 07:02 PM IST
A study led by researchers of Baylor University revealed that the variety in the utilization of market-gained nourishments outside of a traditional diet routine can prove to be a reason for obesity in children, whether they do physical activities or not.
Close
Representational image(Unsplash)
Representational image(Unsplash)

Premature birth can be reduced by treating fetus as patient: Study

ANI
PUBLISHED ON JAN 23, 2021 05:22 PM IST
A new study by scientists of the University of Texas Medical Branch (UTMB) successfully proved the potential for reducing pre-term birth by treating a fetus as a patient with a new drug delivery system developed by ILIAS Biologics, Inc.
Close
Representational image(Unsplash)
Representational image(Unsplash)

Covid-19 triggers antibodies from previous coronavirus infections, says study

PTI
PUBLISHED ON JAN 23, 2021 05:21 PM IST
Covid-19 virus may awaken an antibody response that existed in humans prior to our current pandemic, meaning that we might already have some degree of pre-existing immunity to this virus, one of the study's authors said.
Close
Indians have always used pistachios as a garnish on desserts, biryanis etc.(Pixabay)
Indians have always used pistachios as a garnish on desserts, biryanis etc.(Pixabay)

Boost immunity with key nutrients found in pistachios

ANI, New Delhi [india]
PUBLISHED ON JAN 23, 2021 04:54 PM IST
American Pistachios Growers, a non-profit trade association, organized a Virtual Knowledge Session to talk about the immunity building properties in pistachios and also announce Luke Coutinho as its Lifestyle Ambassador in India.
Close
Sophie Choudry, Yasmin Karachiwala add ‘fun’ to pilates' MOTR workout | Watch(Instagram/sophiechoudry/yasminkarachiwala)
Sophie Choudry, Yasmin Karachiwala add ‘fun’ to pilates' MOTR workout | Watch(Instagram/sophiechoudry/yasminkarachiwala)

Sophie Choudry, Yasmin Karachiwala add ‘fun’ to pilates' MOTR workout | Watch

By Zarafshan Shiraz
PUBLISHED ON JAN 23, 2021 01:16 PM IST
  • Want to improve your basic fitness or need sport-specific conditioning? Check out this ‘fun combo’ of Sophie Choudry and Yasmin Karachiwala as they perform MOTR workout during pilates session at the gym. Read benefits of this exercise form inside
Close
Shilpa Shetty(Instagram)
Shilpa Shetty(Instagram)

Shilpa Shetty shares the perfect exercise, recipe to improve digestive health

By hindustantimes.com | Edited by Alfea Jamal
PUBLISHED ON JAN 23, 2021 12:36 PM IST
Fitness enthusiast, former Bollywood actor and reality show judge Shilpa Shetty often takes to her social media to share her workout routine and diet tips to help her fans get fitter.
Close
SHARE
Story Saved
OPEN APP