Hormone therapy: How Testosterone helps lower heart attack risk

  • AFP, Miami
  • Updated: Apr 05, 2016 12:45 IST
As per a new study in the US, older men who took testosterone treatment seemed to have a lower risk of heart attack than men who did not take it. (Shutterstock)

A recent study done in the US showed that older men with clogged arteries who took testosterone therapy seemed to have a lower heart attack risk than men who did not take it. Testosterone is currently considered risky for the heart, and the US Food and Drug Administration mandated in 2015 that manufacturers of all approved testosterone products add labels to describe these dangers, which include heart attack and stroke.

The methods of the study were observational -- one of the weakest kinds of scientific research -- but its authors said the results should lead to more rigorous trials on the hormone therapy in the future.

Read: Fighting fit | Here’s how you can survive a heart attack

The study by Intermountain Medical Center Heart Institute in Salt Lake City in the US included 755 men, aged 58 to 78, with severe coronary artery disease and low testosterone.

Those who did not take testosterone as part of their follow up were 80 percent more likely to suffer a heart attack, stroke, or death from a cardiovascular event in the next three years.

After a year, 64 patients who were not taking testosterone supplements suffered major adverse cardiovascular events, compared to 21 taking testosterone.

After three years, 125 patients not on testosterone therapy patients suffered major adverse cardiovascular events, compared to 60 patients receiving the hormone.

Read: Shut down a gene, lower the risk of heart attack by 50%

Read: Men with high testosterone may be more honest, says Study

Testosterone is currently considered risky for the heart. (Shutterstock)

The findings were presented at the American College of Cardiology conference in Chicago.

“Although this study indicates that hypo-androgenic men with coronary artery disease might actually be protected by testosterone replacement, this is an observational study that doesn’t provide enough evidence to justify changing treatment recommendations,” said cardiologist Brent Muhlestein, co-director of cardiovascular research at the Intermountain Medical Center Heart Institute.

“It does, however, substantiate the need for a randomized clinical trial that can confirm or refute the results of this study.”

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