Air pollution raises childhood anaemia risk: Research

Meeting air pollution control goals under the National Clean Air Programme (NCAP) could go a long way in improving child health in India, a new research paper has concluded, finding a strong correlation between high outdoor pollution and prevalence of anaemia among children under the age of five years.

A research led by the Centre for Atmospheric Sciences at the Indian Institute of Technology (IIT), Delhi and Harvard University’s TH Chan School of Public Health found that on a district level, for every 10 micrograms per cubic metres increase in outdoor PM2.5 exposure, average anaemia prevalence increased by 1.9% and average haemoglobin level decreased by 0.07 g/dL (grams per decilitre) .

At an individual level ,for every 10 micrograms per cubic metre increase in ambient PM2.5 exposure, average haemoglobin decreased by 0.14 g/dL among children under the age of five. PM 2.5 are fine, inhalable particulate matter with diameters that are generally 2.5 microns, or about 30 times smaller than a strand of human hair.

The researchers used data from the national family and health survey 2015-16 to examine the association of anaemia with high PM 2.5 levels. “We collected the geo-location of the children covered in the National Family Health Survey data. We derived their exposure to PM 2.5 concentrations based on the year of their birth to the time of the survey. The data was adjusted for diet, maternal anaemia prevalence and body mass index all of which has a bearing on anaemia prevalence,” said Sagnik Dey, coordinator of the Centre of Excellence for Research on Clean Air (CERCA) and associate faculty at the School of Public Policy, IIT Delhi. The team used satellite data for calculating air pollution concentrations.

For the district-level analysis, exposure was derived based on the five-year average ambient PM2.5 exposure per district while individual level analysis was based on the year of birth.

“Our analysis reveals that apart from diet and other known causes of anaemia like maternal anaemia, air pollution also plays a significant role in anaemia development and prevalence. We have also discussed the biological mechanism through which air pollution could be a risk factor for anaemia. But that can be only confirmed through a cohort study (studies on groups of people to investigate the causes of a disease),” added Dey.

High air pollution levels have been associated with adverse cardiovascular, respiratory, and mortality outcomes. For children, it has been associated with low birth weight and stunted growth in past research.

As of 2016, nearly 60% of children in India were anaemic. The introduction of the National Iron Plus Initiative in 2011 sought to expand the beneficiaries of the National Nutritional Anaemia Prophylaxis Programme to children aged 6–59 months. “Although anaemia decreased by about 11% between 2006 and 2016, it remains a major issue despite an increase in available food fortified with iron. It is clear that other potential risk factors for childhood anaemia must be identified and understood,” the study observes.

The NCAP doesn’t have a legal mandate but aims to achieve a 20% to 30% reduction in PM 2.5 concentrations from the 2017 levels in over 100 cities by 2024.

“Chronic inflammation can affect the production of red blood cells. It can also affect the way iron moves inside the body or iron trafficking which is mediated by cytokines. We believe that it is the same mechanism by which air pollution raises the risk of low birthweight and preterm births. Inflammation is the biggest link between air pollution and anaemia. But definitely cohort studies would make this linkage clear,” said Kalpana Balakrishnan, the director of the Indian Council of Medical Research (ICMR)’s Centre for Advanced Research on Air Quality, Climate and Health.