Cadila jab immunogenic, safe: Phase 1 trial data

Published on Jul 24, 2021 02:07 AM IST

None of the 48 participants experienced any serious adverse events. However, at least 12 participants reported an adverse event.

The phase I trial, however, had no women participants.(Reuters file photo. )
The phase I trial, however, had no women participants.(Reuters file photo. )
By, Hindustan Times, New Delhi

The DNA vaccine, developed by Indian pharmaceutical company Zydus Cadila, has been found to be safe and immunogenic, according to the 48-participant phase I trial published ahead of print on EClinicalMedicine journal by Lancet. There were no vaccine-related severe adverse events reported and the three-dose vaccine was found to generate good antibody and cellular immunity, the study said.

The phase I trial, however, had no women participants.

The 48 participants were divided into four study arms study two different doses and two different methods of vaccine administration; arm 1 received 1mg dose of the vaccine using needle, arm 2 received 1 mg vaccine intradermally, arm 3 received 2 mg vaccine with needle, and arm 4 received 2 mg vaccine intradermally.

None of the 48 participants experienced any serious adverse events. However, at least 12 participants reported an adverse event. The “solicited” adverse events that were seen in seven of the participants were mild fever, itching, joint pain, tenderness of injection site, and moderate diarrhoea. Most of the events were reported after the administration of the first dose of the vaccine

Get Latest India Newsalong with Latest Newsand Top Headlinesfrom India and around the world.
SHARE THIS ARTICLE ON
  • ABOUT THE AUTHOR

    Anonna Dutt is a health reporter at Hindustan Times. She reports on Delhi government’s health policies, hospitals in Delhi, and health-related feature stories.

SHARE
Story Saved
OPEN APP
×
Saved Articles
Following
My Reads
My Offers
Sign out
New Delhi 0C
Friday, February 03, 2023
Start 15 Days Free Trial Subscribe Now
Register Free and get Exciting Deals