MTV Movie and TV Awards: Avengers Endgame wins best film, Game of Thrones is best show; see full list
Endgame, the second-highest grossing film of all time, picked up the best movie award, as well as best hero for Robert Downey Jr's Iron Man and best villain for Josh Brolin as Thanos.
Oscar-winner Larson added to the superheroes' haul by picking up the best fight award, praising her stunt workers as the "living embodiment of Captain Marvel" as she brought them up on stage.
Joanna Bennett and Renae Moneymaker, who also trained Larson for the first female-led Marvel Studios/Disney superhero film, said it was an "honour" to work on the film and "be a part of bringing such a strong female character to life."
A wide-ranging awards show also paid tribute to women beyond Hollywood such as trailblazing Supreme Court Justice Ruth Bader Ginsburg, the subject of documentary RBG, who won a new category for best real-life hero.
And in the evening's most poignant moment, victims of sexual abuse were honoured by the producers of Surviving R Kelly, which won best documentary.
"Survivors walked through the fire and then stood again to tell this story," said Lifetime network executive Brie Miranda Bryant.
The docu-series has led Chicago prosecutors to publicly seek out potential victims of R&B star Kelly, who has pleaded not guilty to felony sex crime charges.
"This isn't just a trophy to us because this really speaks to the important cultural impact that this generated from this documentary," Bryant added.
Newcomer Noah Centineo was the night's biggest individual winner, scooping awards for breakthrough performance and best kiss alongside Lana Condor for Netflix teen romance film To All The Boys I've Loved Before.
The MTV Movie and TV Awards have been taking a sideways look at Hollywood since 1992, honouring films and their actors with "golden popcorn" statuettes. The nominees are decided by producers and MTV executives, while the winners are chosen by the public, who vote online.
As a result, the awards have historically recognised commercial favourites, in contrast to the Oscars and other events based on critical or industry acclaim. This year it added off-beat new categories for "most meme-able moment" and "reality royalty."
It also gave non-competitive awards to Dwayne ‘The Rock’ Johnson and Jada Pinkett Smith. For the second year running, the show was pre-recorded on Saturday in a cavernous hangar at Santa Monica Airport in southern California.
Here is the full list of winners:
BEST MOVIE: Avengers: Endgame
BEST SHOW: Game of Thrones
BEST PERFORMANCE IN A MOVIE: Lady Gaga - A Star Is Born
BEST PERFORMANCE IN A SHOW: Elisabeth Moss - The Handmaid's Tale
BEST HERO: Robert Downey Jr. - Avengers: Endgame
BEST VILLAIN: Josh Brolin - Avengers: Endgame
BEST KISS: Noah Centineo & Lana Condor - To All the Boys I've Loved Before
REALITY ROYALTY: Love & Hip Hop: Atlanta
BEST COMEDIC PERFORMANCE: Daniel Levy - Schitt's Creek
BREAKTHROUGH PERFORMANCE: Noah Centineo - To All the Boys I've Loved Before
BEST FIGHT: Captain Marvel vs. Minn-Erva - Captain Marvel
BEST REAL-LIFE HERO: Ruth Bader Ginsburg - RBG
MOST FRIGHTENED PERFORMANCE: Sandra Bullock - Bird Box
BEST DOCUMENTARY: Surviving R. Kelly
BEST HOST: Nick Cannon - Wild 'n Out
MOST MEME-ABLE MOMENT: Colton Underwood jumps the fence - The Bachelor
BEST MUSICAL MOMENT: Shallow - A Star Is Born
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