SII is the world’s largest vaccine manufacturer by the number of doses produced and sold globally. (Image for representational purpose only).(AP)
SII is the world’s largest vaccine manufacturer by the number of doses produced and sold globally. (Image for representational purpose only).(AP)

Serum Institute to begin phase 2 trial of Oxford Covid-19 vaccine candidate today

17 sites have been selected to conduct the phase II/III trials, observer-blind, randomized, controlled study, to check the safety and immune response of the vaccine candidate among healthy Indian adults
By Rhythma Kaul | Hindustan Times, New Delhi
PUBLISHED ON AUG 25, 2020 09:57 AM IST

The Serum Institute of India (SII) is set to begin its phase II/III clinical trials of the Oxford University-AstraZeneca Covid-19 vaccine candidate, Covishield, to check its efficacy at Pune’s Bharati Vidyapeeth Deemed University Medical College and Hospital on Tuesday.

SII is the world’s largest vaccine manufacturer by the number of doses produced and sold globally. It has entered a manufacturing partnership with AstraZeneca to produce the vaccine.

Also read: 172 countries engaging with global Covid-19 vaccine plan, says WHO

According to the Clinical Trials Registry of India, 17 sites have been selected to conduct the phase II/III trials, observer-blind, randomized, controlled study, to check the safety and immune response of the vaccine candidate among healthy Indian adults.

Around 1,600 adults above 18 are expected to be recruited for the trials across India. Dr Prasad Kulkarni will be the principal investigator for SII and spearhead the process.

On August 3, India’s drugs controller gave approval to SII for conducting phase II and III clinical trials of the vaccine candidate in the country. The results of its phase I trial held in the UK had shown promise in generating an immune response against SARS-CoV-2, the virus that causes Covid-19.

Covishield will be administered as a two-dose schedule on days 1 and 29 as 0.5 ml dose intramuscularly. Placebo will be administered as a two-dose schedule on days 1 and 29 as 0.5 ml dose intramuscularly.

The vaccine is made from a weakened version of a common cold adenovirus taken from chimps and genetically modified.

Even though confirming that the trial process has started, representatives of SII have been declining to divulge more details regarding the development.

In a statement issued on Sunday, SII said, “The phase-3 trials for the Oxford-AstraZeneca vaccine are still underway. And only once the vaccine is proven immunogenic and efficacious, SII will confirm its availability, officially. COVISHIELD will be commercialized once the trials are proven successful and all the requisite regulatory approvals are in place. …Presently, the government has granted us permission to only manufacture the vaccine and stockpile it for future use.”

SHARE THIS ARTICLE ON
Close
Rescheduling of an appointment has to be done before the appointment day.
Rescheduling of an appointment has to be done before the appointment day.

5 things to keep in mind while registering on Co-Win for covid-19 vaccine

By hindustantimes.com | Edited by Poulomi Ghosh
PUBLISHED ON MAR 03, 2021 11:57 AM IST
Confirmation details have to be download, rescheduling can be done only before the appointment day.
Close
Landslide occured at Shabanbas Banihal in the wee hours of Wednesday.(ANI file photo)
Landslide occured at Shabanbas Banihal in the wee hours of Wednesday.(ANI file photo)

Landslide blocks Srinagar-Jammu national highway, restoration work underway

ANI, Srinagar
PUBLISHED ON MAR 03, 2021 11:15 AM IST
According to the India Meteorological Department (IMD), a fresh feeble Western Disturbance as a cyclonic circulation lies over Jammu and Kashmir.
Close
Prime Minister Narendra Modi on Wednesday discussed the steps taken in this year’s budget for the education sector.
Prime Minister Narendra Modi on Wednesday discussed the steps taken in this year’s budget for the education sector.

Education second biggest focus of Union Budget 2021, says PM Modi

By hindustantimes.com | Edited by Poulomi Ghosh
UPDATED ON MAR 03, 2021 11:16 AM IST
The budget has broadened India's efforts to link education with employability and entrepreneurial capability, PM Modi said.
Close
Naveen Patnaik government is starting an OBC survey to study their social and educational status in the state. The last such survey is 90-years old.(HT photo)
Naveen Patnaik government is starting an OBC survey to study their social and educational status in the state. The last such survey is 90-years old.(HT photo)

Odisha: Opposition says OBC survey bid to create vote bank by Naveen Patnaik

By Debabrata Mohanty | Edited by Abhinav Sahay, Bhubaneswar
PUBLISHED ON MAR 03, 2021 11:10 AM IST
  • A former state minister said that the OBC survey was an attempt to create an OBC votebank and this would be the first instance in Odisha of influencing voting as per caste lines.
Close
Goa’s mining industry came to a halt in March 2018 after the Supreme Court ruled that the mining lease renewals granted by the state government were not as per law.(HT PHOTO)
Goa’s mining industry came to a halt in March 2018 after the Supreme Court ruled that the mining lease renewals granted by the state government were not as per law.(HT PHOTO)

Goa ecologists, miners oppose Centre’s proposed amendments to mining act

By Gerard de Souza | Edited by Abhinav Sahay
PUBLISHED ON MAR 03, 2021 10:21 AM IST
  • Goa Mineral Ore Exporters Association (GMOEA), a body of mine owners, said they have written to the Centre expressing reservations over the proposed amendments.
Close
(FILES) In this file photo taken on November 29, 2017, a man checks his cell phone as he waits in line to enter the US Supreme Court to view a hearing in Washington, DC, Carpenter v. United States on whether prosecutors violated the Fourth Amendment by collecting a criminal suspect's cellphone location and movement data without a warrant. In a landmark digital privacy case, the US Supreme Court ruled Friday, June 22, 2018, that police need a warrant before obtaining cell phone location data about a suspect from telecom companies. In a 5-4 decision, the nation's highest court said that cell phone location data is protected under the Fourth Amendment, which guards against unreasonable search and seizure. The case stemmed from the police acquiring mobile phone location information about a robbery suspect without a warrant. / AFP PHOTO / GETTY IMAGES NORTH AMERICA / ALEX WONG (AFP)
(FILES) In this file photo taken on November 29, 2017, a man checks his cell phone as he waits in line to enter the US Supreme Court to view a hearing in Washington, DC, Carpenter v. United States on whether prosecutors violated the Fourth Amendment by collecting a criminal suspect's cellphone location and movement data without a warrant. In a landmark digital privacy case, the US Supreme Court ruled Friday, June 22, 2018, that police need a warrant before obtaining cell phone location data about a suspect from telecom companies. In a 5-4 decision, the nation's highest court said that cell phone location data is protected under the Fourth Amendment, which guards against unreasonable search and seizure. The case stemmed from the police acquiring mobile phone location information about a robbery suspect without a warrant. / AFP PHOTO / GETTY IMAGES NORTH AMERICA / ALEX WONG (AFP)

Manipur DM issues notice under new digital rules, withdraws it: See details here

By HT Correspondent | Edited by Sameer
PUBLISHED ON MAR 03, 2021 10:09 AM IST
The notice was issued over a talk show on current affairs and news hosted on a social media platform under the Information Technology (Intermediary Guidelines and Digital Media Ethics Code) Rules, 2021, notified on February 25
Close
Elderly people wait for their turn to get vaccinated with Covid-19 vaccine, at a vaccination centre in Thane,(PTI)
Elderly people wait for their turn to get vaccinated with Covid-19 vaccine, at a vaccination centre in Thane,(PTI)

With 14,989 fresh Covid-19 infections, India's active cases surge past 1.7 lakh

By hindustantimes.com | Edited by Poulomi Ghosh
UPDATED ON MAR 03, 2021 10:02 AM IST
On Tuesday, India's active cases were around 1.68 lakh. But in the last 24 hours, India reported more infections than recoveries.
Close
On Tuesday morning, the Delhi Police briefly opened the Ghazipur border for traffic only to be closed in the afternoon. The entry and exit points between Delhi and Haryana, passing through Singhu, Tikri, Auchandi, Piau Maniyari and Saboli and Mangesh continue to remain closed. (PTI)
On Tuesday morning, the Delhi Police briefly opened the Ghazipur border for traffic only to be closed in the afternoon. The entry and exit points between Delhi and Haryana, passing through Singhu, Tikri, Auchandi, Piau Maniyari and Saboli and Mangesh continue to remain closed. (PTI)

News updates from HT | Farmers’ protest: Multiple Delhi borders closed

PUBLISHED ON MAR 03, 2021 09:39 AM IST
Here are today’s top news, analysis and opinion. Know all about the latest news and other news updates from Hindustan Times.
Close
Congress leader Rahul Gandhi. (PTI)
Congress leader Rahul Gandhi. (PTI)

Amid row over Azad, J&K Congress leaders meet Rahul Gandhi

PUBLISHED ON MAR 03, 2021 09:35 AM IST
The leaders apprised Gandhi about the current state of affairs on the political front and the activities of the party in Jammu and Kashmir, said an official statement issued here
Close
The streaming service on Tuesday issued an apology to its Indian viewers for offending some sentiments.
The streaming service on Tuesday issued an apology to its Indian viewers for offending some sentiments.

'Tandav' row: SC to hear Amazon Prime head's anticipatory bail plea

By hindustantimes.com | Edited by Poulomi Ghosh
UPDATED ON MAR 03, 2021 10:11 AM IST
In January, Aparna Purohit, 'Tandav' actor Mohammad Zeeshan Ayyub, and the makers had approached the Supreme court seeking protection from arrest on the FIRs. The top court at that time denied granting interim protection
Close
Representational Image. (File photo)
Representational Image. (File photo)

EC meets revenue officials ahead of assembly polls

By Deeksha Bhardwaj
PUBLISHED ON MAR 03, 2021 09:17 AM IST
The EC has issued directions for strict action against any financial misconduct in the elections. Around 187 million people in West Bengal, Assam, Kerala, Tamil Nadu, and Puducherry will vote to elect 824 lawmakers from March 27
Close
Union minister Ravi Shankar Prasad and Bihar BJP chief Sanjay Jaiswal held a meeting in favour of the farm laws in Patna.(Sonu Mehta/HT PHOTO)
Union minister Ravi Shankar Prasad and Bihar BJP chief Sanjay Jaiswal held a meeting in favour of the farm laws in Patna.(Sonu Mehta/HT PHOTO)

Notice served under new IT rules in Manipur, withdrawn

By Utpal Parashar, Sunetra Choudhury, Guwahati, New Delhi
PUBLISHED ON MAR 03, 2021 09:14 AM IST
  • The notice under the Information Technology (Intermediary Guidelines and Digital Media Ethics Code) Rules, 2021 notified on February 25, was issued on March 1 and served on Tuesday morning to the publisher/intermediary of Khanasi Neinasi, which means Let’s Talk in Manipuri.
Close
Representational image. (Getty Images/iStockphoto)
Representational image. (Getty Images/iStockphoto)

NIA arrests BSF officer for helping cross-border drug smugglers

By Neeraj Chauhan
PUBLISHED ON MAR 03, 2021 09:08 AM IST
Romesh Kumar is the second security person to be arrested in Jammu & Kashmir since January 2020 for allegedly helping terrorists
Close
Senior citizens at BKC in Mumbai waiting for vaccine registration on Tuesday. Photo by Pratik Chorge
Senior citizens at BKC in Mumbai waiting for vaccine registration on Tuesday. Photo by Pratik Chorge

More private hospitals to become vaccine sites, Centre allows states to decide

By hindustantimes.com | Edited by Poulomi Ghosh
UPDATED ON MAR 03, 2021 08:50 AM IST
The Centre has also asked states to not store vaccines or to create a buffer stock, apprehending any future shortage.
Close
A boy sells a water pot for summer days at Sahakar nagar in Pune, India, on Sunday, February 28. (Rahul Raut/HT photo)
A boy sells a water pot for summer days at Sahakar nagar in Pune, India, on Sunday, February 28. (Rahul Raut/HT photo)

High maximum temperatures to persist for another 4-5 days: IMD

By HT Correspondent | Edited by Smriti Sinha
PUBLISHED ON MAR 03, 2021 08:17 AM IST
A feeble Western Disturbance as a cyclonic circulation over north Pakistan is persisting. Under its influence, isolated rainfall/snowfall is likely over Jammu, Kashmir, Ladakh, Gilgit, Baltistan, Muzaffarabad, Himachal Pradesh and Uttarakhand on March 3 and 4
Close
SHARE
Story Saved
OPEN APP