A woman was killed and twenty others, including three children, were injured in a blast near Northeast Frontier railway colony in Bamuni Maidan area on Saturday night.
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The injured have been admitted to a nearby private hospital and the Guwahati Medical College (GMC) Hospital at Bhangaghar area.
Officials suspect ULFA's hand behind the blasts.
The bomb went off in a market area near the railway tracks outside the colony near gate number six, Senior Superintendent of Police Nitul Gogoi said.
The deceased woman has been identified as S Begum, 50.
The area has now been cordoned off, the officer added.