UK surgeon says ‘your gut controls way more than your poops’; explains how the gut-organ axis impacts bodily functions

A lot of your health issues can clear up once you start taking care of your gut. Dr Rajan explains how the gut microbiome controls different organs.
Breakouts that won’t clear, frequent colds, low energy or unexplained mood swings may not just be skin-deep or stress-related - your gut could be at the root of it. Far from being responsible only for digestion, the gut plays a central role in immunity, metabolism, brain function and even skin health. When gut balance is off, its effects can ripple through the entire body - and fixing it can often improve multiple health concerns at once.
Karan Rajan, a UK-based surgeon and popular health content creator, is breaking down why optimal gut health is essential for the proper functioning of multiple organs - explaining that the gut influences far more than just digestion and bowel movements. In an Instagram video shared on January 13, the surgeon explains the gut-organ axis, highlighting how gut health directly influences the functioning and regulation of other organs throughout the body.
The gut-organ axis
According to Dr Rajan, your gut controls much more than just your bowel movements. The microbes in your digestive tract communicate with different organs - the brain, skin, hormones, and even immune system - and these organs function according to how healthy your gut microbiome is.
He explains, “Your gut controls way more than your poops. Inside you is a 30-foot digestive tract hosting trillions of microbes. These chat with your brain, your skin, your hormones, even your immune system - and it's called the gut organ axis.”
Gut and brain
The surgeon highlights that your gut can be responsible for how you feel - fogginess, irritability, anxiety - by producing neurotransmitters that regulate mood and motivation.
He states, “Your gut makes neurotransmitters linked to mood, motivation, and feeling human. So when your gut microbes are unhappy, your brain feels the reflections of your gut state, which can manifest as fogginess, irritability, and anxiety spikes. But consistency helps. Most people feel mood and energy hits within two to four weeks of supporting their gut.”
Gut and skin
Skin problems like acne, eczema and even dullness can be linked to the gut, according to Dr Rajan. He explains, “If your gut lining gets irritated, tiny inflammatory molecules leak into the bloodstream and head straight to your skin. Improvements usually take four to eight weeks. That's the average skin turnover cycle.”
Gut and immunity
The surgeon highlights that nearly 70 percent of the immune system resides in the gut, with gut microbes playing a crucial role in shaping how strong, responsive and resilient your immune system is.
He explains, “At least 70 percent of your immune system lives in the gut. Your microbes train it like little personal trainers and when things in your gut are off, you get a higher chance of colds and illnesses. Immune steadiness typically builds up over eight to 12 weeks of consistent habits.”
Gut and metabolic health
The gut microbiome also influences key metabolic markers such as blood sugar levels, insulin sensitivity, appetite and satiety signals, while even determining how many calories the body ultimately absorbs from food.
Dr Rajan elaborates, “Your microbes influence blood sugar, insulin sensitivity, cravings, fullness signals, and even how many calories you absorb from food. Two people can eat the same meal and absorb different calories based on their microbiome. Metabolic improvements to your health show up around three to six weeks.”
The surgeon highlights that your gut thrives on consistency, and feeding it the right foods and keeping healthy gut habits can help repair it. He concludes, “You cannot fix your gut in a weekend. There's no one food, one tea, one hack. Your gut runs on consistency and small daily habits repeated often.”
Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. It is based on user-generated content from social media. HT.com has not independently verified the claims and does not endorse them.
ABOUT THE AUTHOREshana SahaEshana Saha is a fresh face in lifestyle and cultural journalism, bringing a refined, multidisciplinary perspective to the intersection of entertainment, fashion and holistic wellbeing. With less than a year of professional experience, she has quickly adapted to high-pressure editorial environments and currently works full-time with HT Media. Prior to this, she interned for nearly six months with Hindustan Times’ entertainment and lifestyle vertical, where she gained hands-on experience in digital reporting, trend analysis and editorial storytelling. Based in New Delhi, Eshana specialises in comprehensive coverage of major cultural moments — from international film press tours to the curated aesthetics of global fashion showcases, award shows and music-centred events. She holds a Bachelor’s degree in English from St Xavier’s University, Kolkata, and a Master’s degree in English from the University of Delhi, equipping her with a strong academic foundation and a keen ability to deconstruct complex cultural trends into clear, high-impact narratives. Beyond the red carpet, Eshana has developed a growing focus on health and wellbeing reporting. She bridges the gap between celebrity-driven trends and practical, evidence-informed lifestyle advice, ensuring her work remains both aspirational and grounded in editorial rigour. She has extensively covered the health implications of Delhi’s air pollution crisis, while also playing a key role in amplifying expert-led insights on women’s health and mental wellbeing, helping translate complex medical perspectives into informed, impactful public awareness. An artist at heart, she explores multiple creative forms — from visual arts and music to culinary experiments — and brings a creative’s eye for nuance, texture and detail to every story. Whether analysing runway dynamics or examining emerging wellness movements, she remains committed to accuracy and the highest standards of contemporary journalistic ethics.Read More
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