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Home / World News / Antiviral drug shows some hope in US govt-run study

Antiviral drug shows some hope in US govt-run study

Gilead shares jumped as much as 7.1% Wednesday after the company’s statement. The news appeared to boost the entire U.S. stock market as well, with the S&P 500 gaining 2.4% despite data showing a deep contraction in the U.S. economy in the first quarter of the year.

world Updated: Apr 30, 2020 04:56 IST
Bloomberg
Bloomberg
New York
The company issued a news release early Wednesday commenting on the study from the U.S. National Institute of Allergy and Infectious Diseases without providing details of the results.
The company issued a news release early Wednesday commenting on the study from the U.S. National Institute of Allergy and Infectious Diseases without providing details of the results.(REUTERS)

Gilead Sciences Inc. said early results from a US-government-run study showed its experimental drug to treat coronavirus helped patients recover more quickly than standard care, suggesting it could become the first effective treatment for an illness that has turned modern life inside-out.

Gilead shares jumped as much as 7.1% Wednesday after the company’s statement. The news appeared to boost the entire U.S. stock market as well, with the S&P 500 gaining 2.4% despite data showing a deep contraction in the U.S. economy in the first quarter of the year.

The company issued a news release early Wednesday commenting on the study from the U.S. National Institute of Allergy and Infectious Diseases without providing details of the results.

Anthony Fauci, the head of NIAID and the government’s top infectious-disease specialist, said at a White House meeting with President Donald Trump and Louisiana Governor John Bel Edwards that the trial showed a significant positive effect on the virus and that the results “were quite good news.”

Fauci called the study the “first truly high-powered randomized placebo-controlled trial” of remdesivir.

Gilead’s share price and the broader stock market have been churned in recent weeks by a series of early looks and leaks of trial data on the drug, called remdesivir. Last week, the market swooned after apparently discouraging results from a Chinese trial were accidentally posted on a World Health Organization web page. Data confirming those more downbeat results were published in the U.K. medical journal The Lancet on Wednesday.

Remdesivir, which was originally developed to treat other novel viruses, has placed Gilead at the head of the race to develop a treatment for Covid-19. The drug, which has also been tested on Ebola, hasn’t been approved for use anywhere in the world.

A separate study released by Gilead on Wednesday said remdesivir appears equally effective when it’s given over just five days, rather than the 10-day course used in NIAID and other trials. But the Gilead study doesn’t have a comparison group.

The five-day regimen “could significantly expand the number of patients who could be treated with our current supply of remdesivir,” said Merdad Parsey, Gilead’s chief medical officer.

Taken together, the studies could signal a profound shift in the race to get the novel coronavirus under control. The availability of a treatment could allow the world to start reopening economies, as well as offer psychological relief to billions of people who have been self-isolating to hide from the virus.

In the most severe cases, Covid-19 can lead to respiratory failure and death. More than 1 million cases have been confirmed in the U.S., and over 200,000 people have died around the globe from the illness.

Multiple trials of the drug are being conducted. The NIAID trial measured how quickly patients taking it were able to be removed from supplemental oxygen therapy or were discharged from the hospital. It’s not known yet how much benefit the Gilead drug gave patients, and if it will make a meaningful difference in their care.

The trial, run by the National Institutes of Health, aimed to sign up about 800 patients to test the drug and give a definitive answer as to whether it can help treat the illness.

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